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Lateral entorhinal cortex lesions impair both egocentric and allocentric object-place associations

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Lateral entorhinal cortex lesions impair both egocentric and allocentric object-place associations. / Kuruvilla, Maneesh V.; Wilson, David I. G.; Ainge, James A.

In: Brain and Neuroscience Advances, Vol. 4, 14.07.2020, p. 1-11.

Research output: Contribution to journalArticlepeer-review

Harvard

Kuruvilla, MV, Wilson, DIG & Ainge, JA 2020, 'Lateral entorhinal cortex lesions impair both egocentric and allocentric object-place associations', Brain and Neuroscience Advances, vol. 4, pp. 1-11. https://doi.org/10.1177/2398212820939463

APA

Kuruvilla, M. V., Wilson, D. I. G., & Ainge, J. A. (2020). Lateral entorhinal cortex lesions impair both egocentric and allocentric object-place associations. Brain and Neuroscience Advances, 4, 1-11. https://doi.org/10.1177/2398212820939463

Vancouver

Kuruvilla MV, Wilson DIG, Ainge JA. Lateral entorhinal cortex lesions impair both egocentric and allocentric object-place associations. Brain and Neuroscience Advances. 2020 Jul 14;4:1-11. https://doi.org/10.1177/2398212820939463

Author

Kuruvilla, Maneesh V. ; Wilson, David I. G. ; Ainge, James A. / Lateral entorhinal cortex lesions impair both egocentric and allocentric object-place associations. In: Brain and Neuroscience Advances. 2020 ; Vol. 4. pp. 1-11.

Bibtex - Download

@article{b5b2058dae97498d8cb946696fa87bdf,
title = "Lateral entorhinal cortex lesions impair both egocentric and allocentric object-place associations",
abstract = "During navigation, landmark processing is critical either for generating an allocentric-based cognitive map or in facilitating egocentric-based strategies. Increasing evidence from manipulation and single-unit recording studies has highlighted the role of the entorhinal cortex in processing landmarks. In particular, the lateral (LEC) and medial (MEC) sub-regions of the entorhinal cortex have been shown to attend to proximal and distal landmarks, respectively. Recent studies have identified a further dissociation in cue processing between the LEC and MEC based on spatial frames of reference. Neurons in the LEC preferentially encode egocentric cues while those in the MEC encode allocentric cues. In this study, we assessed the impact of disrupting the LEC on landmark-based spatial memory in both egocentric and allocentric reference frames. Animals that received excitotoxic lesions of the LEC were significantly impaired, relative to controls, on both egocentric and allocentric versions of an object–place association task. Notably, LEC lesioned animals performed at chance on the egocentric version but above chance on the allocentric version. There was no significant difference in performance between the two groups on an object recognition and spatial T-maze task. Taken together, these results indicate that the LEC plays a role in feature integration more broadly and in specifically processing spatial information within an egocentric reference frame.",
keywords = "Hippocampus, Spatial memory, Associative, Episodic memory, Navigation, Medial entorhinal cortex, Cognitive map, Landmarks",
author = "Kuruvilla, {Maneesh V.} and Wilson, {David I. G.} and Ainge, {James A.}",
note = "This work was supported by Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/I019367/1.",
year = "2020",
month = jul,
day = "14",
doi = "10.1177/2398212820939463",
language = "English",
volume = "4",
pages = "1--11",
journal = "Brain and Neuroscience Advances",
issn = "2398-2128",
publisher = "Sage",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Lateral entorhinal cortex lesions impair both egocentric and allocentric object-place associations

AU - Kuruvilla, Maneesh V.

AU - Wilson, David I. G.

AU - Ainge, James A.

N1 - This work was supported by Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/I019367/1.

PY - 2020/7/14

Y1 - 2020/7/14

N2 - During navigation, landmark processing is critical either for generating an allocentric-based cognitive map or in facilitating egocentric-based strategies. Increasing evidence from manipulation and single-unit recording studies has highlighted the role of the entorhinal cortex in processing landmarks. In particular, the lateral (LEC) and medial (MEC) sub-regions of the entorhinal cortex have been shown to attend to proximal and distal landmarks, respectively. Recent studies have identified a further dissociation in cue processing between the LEC and MEC based on spatial frames of reference. Neurons in the LEC preferentially encode egocentric cues while those in the MEC encode allocentric cues. In this study, we assessed the impact of disrupting the LEC on landmark-based spatial memory in both egocentric and allocentric reference frames. Animals that received excitotoxic lesions of the LEC were significantly impaired, relative to controls, on both egocentric and allocentric versions of an object–place association task. Notably, LEC lesioned animals performed at chance on the egocentric version but above chance on the allocentric version. There was no significant difference in performance between the two groups on an object recognition and spatial T-maze task. Taken together, these results indicate that the LEC plays a role in feature integration more broadly and in specifically processing spatial information within an egocentric reference frame.

AB - During navigation, landmark processing is critical either for generating an allocentric-based cognitive map or in facilitating egocentric-based strategies. Increasing evidence from manipulation and single-unit recording studies has highlighted the role of the entorhinal cortex in processing landmarks. In particular, the lateral (LEC) and medial (MEC) sub-regions of the entorhinal cortex have been shown to attend to proximal and distal landmarks, respectively. Recent studies have identified a further dissociation in cue processing between the LEC and MEC based on spatial frames of reference. Neurons in the LEC preferentially encode egocentric cues while those in the MEC encode allocentric cues. In this study, we assessed the impact of disrupting the LEC on landmark-based spatial memory in both egocentric and allocentric reference frames. Animals that received excitotoxic lesions of the LEC were significantly impaired, relative to controls, on both egocentric and allocentric versions of an object–place association task. Notably, LEC lesioned animals performed at chance on the egocentric version but above chance on the allocentric version. There was no significant difference in performance between the two groups on an object recognition and spatial T-maze task. Taken together, these results indicate that the LEC plays a role in feature integration more broadly and in specifically processing spatial information within an egocentric reference frame.

KW - Hippocampus

KW - Spatial memory

KW - Associative

KW - Episodic memory

KW - Navigation

KW - Medial entorhinal cortex

KW - Cognitive map

KW - Landmarks

U2 - 10.1177/2398212820939463

DO - 10.1177/2398212820939463

M3 - Article

VL - 4

SP - 1

EP - 11

JO - Brain and Neuroscience Advances

JF - Brain and Neuroscience Advances

SN - 2398-2128

ER -

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