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Leptin integrates vertebrate evolution: From oxygen to the blood-gas barrier

Research output: Contribution to journalReview article


J. S. Torday, F. L. Powell, C. G. Farmer, S. Orgeig, H. C. Nielsen, A. J. Hall

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The following are the proceedings of a symposium held at the Second International Congress for Respiratory Science in Bad Honnef, Germany The goals of the symposium were to delineate the blood-gas barrier phenotype across vertebrate species, to delineate the interrelationship between the evolution of the blood-gas barrier, locomotion and metabolism: to introduce the selection pressures for the evolution of the surfactant system as a key to understanding the physiology of the blood-gas barrier, to introduce the lung lipofibroblast and its product. leptin, which coordinately regulates pulmonary surfactant, type IV collagen in the basement membrane and host defense, as the cell-molecular site of selection pressure for the blood-gas barrier, to drill down to the gene regulatory network(s) involved in leptin signaling and the blood-gas barrier phenotype, to extend the relationship between leptin and the blood-gas barrier to diving mammals. (C) 2010 Elsevier B.V All rights reserved



Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalRespiratory Physiology & Neurobiology
Publication statusPublished - 31 Aug 2010

    Research areas

  • Evolution of the blood-gas barrier, structure and function of the blood-gas barrier, Constraints on the blood-gas barrier, The surfactant system and evolution of the blood-gas barrier, Leptin and the evolution of the blood-gas barrier, Leptin signaling, the epidermal growth factor pathway, and formation and homeostatic regulation of the blood-gas barrier, Evolution of the blood-gas barrier in diving mammals, MARSUPIAL SMINTHOPSIS-CRASSICAUDATA, PULMONARY SURFACTANT SYSTEM, GOULDS WATTLED BAT, DIVING MAMMALS, MARINE MAMMALS, LUNG DEVELOPMENT, RAPID AROUSAL, PHYSIOLOGY, TORPOR, STIMULATION

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