Skip to content

Research at St Andrews

Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats

Research output: Research - peer-reviewArticle

DOI

Abstract

The cholinergic neurons of the basal forebrain, which project to cortex, the thalamic reticular nucleus and the amygdala, are implicated in many aspects of attentional function, while the intrinsic neurons of the basal forebrain are implicated in learning and memory. This study compared the effects of lesions of the basal forebrain made with either the immunotoxin 192-IgG-saporin (which selectively destroys cholinergic neurons), or the non-selective excitotoxin, ibotenic acid (which destroys both cholinergic and non-cholinergic neurons) on a task which measure the acquisition and shifting of attentional set as well as the ability to learn reversals of specific stimulus-reward pairings. Rats learned to obtain food reward by digging in small bowls containing distinctive digging media that were differentially scented with distinct odours. They performed a series of two-choice discriminations, with the bait associated with either the odour or the digging medium. Rats with 192-IgG-saporin lesions of the basal forebrain were not impaired relative to control rats at any stage of the task. Rats with ibotenic acid lesions of the basal forebrain were impaired the first time stimulus-reward contingencies were reversed. They were not impaired in acquisition of new discriminations, even when an attentional-shift was required. These data are consistent with data from marmosets and so highlight the functional similarity of monkey and rodent basal forebrain. They also confirm the likely involvement of non-cholinergic neurons of the basal forebrain in reversal learning. (C) 2007 Elsevier B.V. All rights reserved.

Close

Details

Original languageEnglish
Pages (from-to)100-108
Number of pages9
JournalBehavioural Brain Research
Volume187
Issue number1
Early online date4 Sep 2007
DOIs
StatePublished - 11 Feb 2008

    Research areas

  • attentional set-shifting, 192-IgG-saporin, ibotenic acid, GABAergic, basal forebrain, reversal learning, 192 IGG-SAPORIN, CHOLINERGIC NEURONS, EXCITOTOXIC LESIONS, PREFRONTAL CORTEX, FRONTAL-CORTEX, NUCLEUS, 192-IGG-SAPORIN, MAGNOCELLULARIS, ACETYLCHOLINE, DISSOCIATION

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Assessment of intradimensional/extradimensional attentional set-shifting in rats

    Tait, D. S., Bowman, E. M., Neuwirth, L. S. & Brown, V. J. 21 Feb 2018 In : Neuroscience and Biobehavioral Reviews. 89, p. 72-84 13 p.

    Research output: Research - peer-reviewReview article

  2. Oral dosing of rodents using a palatable tablet

    Dhawan, S. S., Xia, S., Tait, D. S., Bundgaard, C., Bowman, E. & Brown, V. J. May 2018 In : Psychopharmacology. 235, 5, p. 1527-1532 6 p.

    Research output: Research - peer-reviewArticle

  3. Effects of lesions of the subthalamic nucleus/zona incerta area and dorsomedial striatum on attentional set-shifting in the rat

    Tait, D. S., Phillips, J. M., Blackwell, A. D. & Brown, V. J. 14 Mar 2017 In : Neuroscience. 345, p. 287-296 10 p.

    Research output: Research - peer-reviewArticle

  4. Attentional set-shifting in rodents: a review of behavioural methods and pharmacological results

    Tait, D. S., Chase, E. A. & Brown, V. J. 2014 In : Current Pharmaceutical Design. 20, 31, p. 5046-59

    Research output: Research - peer-reviewReview article

  5. Tacrine improves reversal learning in older rats

    Tait, D. S., Chase, A. & Brown, V. J. Oct 2013 In : Neuropharmacology. 73, p. 284–289 6 p.

    Research output: Research - peer-reviewArticle

Related by journal

  1. Experience affects immediate early gene expression in response to conspecific call notes in black-capped chickadees (Poecile atricapillus)

    Hahn, A. H., Guillette, L. M., Lee, D., McMillan, N., Hoang, J. & Sturdy, C. B. 1 Jul 2015 In : Behavioural Brain Research. 287, p. 49-58 10 p.

    Research output: Research - peer-reviewArticle

  2. Neural correlates of nesting behavior in zebra finches (Taeniopygia guttata)

    Hall, Z. J., Bertin, M., Bailey, I. E., Meddle, S. L. & Healy, S. D. 1 May 2014 In : Behavioural Brain Research. 264, p. 26-33 8 p.

    Research output: Research - peer-reviewArticle

  3. Discrimination reversal and attentional sets in zebrafish (danio rerio)

    Parker, M. O., Gaviria, J., Haigh, A., Millington, M. E., Brown, V. J., Combe, F. J. & Brennan, C. 15 Jun 2012 In : Behavioural Brain Research. 232, p. 264-268 4 p.

    Research output: Research - peer-reviewArticle

ID: 424979