Skip to content

Research at St Andrews

Lesions of the orbital prefrontal cortex impair the formation of attentional set in rats

Research output: Contribution to journalArticle

Abstract

In rats, reversal learning impairments are commonly reported after lesions of the orbital prefrontal cortex (OFC), in contrast to the effect of lesions of the medial prefrontal cortex, which impair attentional set-shifting. Comparable dissociations have also been reported in humans, monkeys and mice. However, these two manifestations of behavioural flexibility may share common cognitive
processes. The present study tested the hypothesis that lesions of the OFC (an area that integrates expected and actual outcomes to signal which cues in the environment predict reward) would impair the formation of attentional set as well as impairing reversal learning. We compared the performance of lesioned and control rats on two set-shifting tasks. The first task we used, ‘the 4ID task’,
had no reversal stages, but multiple intradimensional acquisitions before the extradimensional shift stage, to assess set-formation as well as set-shifting. The second task was the standard intradimensional ⁄ extradimensional ‘7-stage task’, which includes reversal learning stages after each compound acquisition. Compared with controls, lesioned rats were slower to form attentional set on the
4ID task. When they did form a set, they required more trials to complete the extradimensional shift stage. On the 7-stage task, we replicated our previous finding of impaired reversal learning and reduced shift-costs. We interpret these findings as reflecting a single deficit in identifying relevant cues after unexpected outcomes, which supports recent models of OFC function. Our findings challenge the assumption that the contribution of the OFC to behavioural flexibility is limited to reversal learning.
Close

Details

Original languageEnglish
Pages (from-to)2368-2375
JournalEuropean Journal of Neuroscience
Volume36
Issue number3
Early online date4 Jun 2012
DOIs
Publication statusPublished - Aug 2012

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Assessment of intradimensional/extradimensional attentional set-shifting in rats

    Tait, D. S., Bowman, E. M., Neuwirth, L. S. & Brown, V. J., Jun 2018, In : Neuroscience and Biobehavioral Reviews. 89, p. 72-84 13 p.

    Research output: Contribution to journalReview article

  2. Oral dosing of rodents using a palatable tablet

    Dhawan, S. S., Xia, S., Tait, D. S., Bundgaard, C., Bowman, E. & Brown, V. J., May 2018, In : Psychopharmacology. 235, 5, p. 1527-1532 6 p.

    Research output: Contribution to journalArticle

  3. Effects of lesions of the subthalamic nucleus/zona incerta area and dorsomedial striatum on attentional set-shifting in the rat

    Tait, D. S., Phillips, J. M., Blackwell, A. D. & Brown, V. J., 14 Mar 2017, In : Neuroscience. 345, p. 287-296 10 p.

    Research output: Contribution to journalArticle

Related by journal

  1. The neuronal migration hypothesis of dyslexia: a critical evaluation 30 years on

    Guidi, L. G., Velayos-Baeza, A., Martinez-Garay, I., Monaca, A. P., Paracchini, S., Bishop, D. V. M. & Molnár, Z., Nov 2018, In : European Journal of Neuroscience. 48, 10, p. 3212-3233 22 p.

    Research output: Contribution to journalReview article

  2. Visual system integrity and cognition in early Huntington's disease

    Wolf, R. C., Sambataro, F., Vasic, N., Baldas, E-M., Ratheiser, I., Landwehrmeyer, G. B., Depping, M. S., Thomann, P. A., Sprengelmeyer, R. H., Süssmuth, S. S. & Orth, M., Jul 2014, In : European Journal of Neuroscience. 40, 2, p. 2417–2426 10 p.

    Research output: Contribution to journalArticle

  3. Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury

    Zhao, R., Andrews, M. R., Wang, D., Warren, P., Gullo, M., Schnell, L., Schwab, M. E. & Fawcett, J. W., Sep 2013, In : European Journal of Neuroscience. 38, 6, p. 2946-2961

    Research output: Contribution to journalArticle

  4. Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine

    Wilson, D. I. G., MacLaren, D. A. A. & Winn, P., Aug 2009, In : European Journal of Neuroscience. 30, 3, p. 504-513 10 p.

    Research output: Contribution to journalArticle

ID: 22108617

Top