Skip to content

Research at St Andrews

Localization of a novel t(1;7) translocation associated with Wilms' tumor predisposition and skeletal abnormalities

Research output: Contribution to journalArticle

Author(s)

Paul Andrew Reynolds, R Powlesland, TJ Keen, C Inglehearn, AE Cunningham, ED Green, KW Brown

School/Research organisations

Abstract

Cytogenetic analysis of predisposition syndromes has played a critical role in the elucidation of the genetics of Wilms' tumor (WT). Therefore, we became interested in a patient who presented with a WT and a nephrogenic rest in the contralateral kidney (suggestive of a predisposition) and a de novo t(1;7)(q42;p15) constitutional translocation as the only visible cytogenetic abnormality. He also had bilateral radial aplasia and other skeletal abnormalities, but there was no manifestation of any syndrome previously associated with WT. In the tumor, the translocation was retained, and the other 7p region was lost by the formation of an isochromosome i(7q). Here, we report the localization of the chromosome 7 breakpoint within a yeast artificial chromosome (YAC) contig by using fluorescence in situ hybridization (FISH), localizing the breakpoint between markers sWSS355 and sWSS1449. A number of YACs span the breakpoint and, thus, contain the region that is disrupted by the translocation. This may represent the site of a novel tumor suppressor gene that is involved in WT and also in normal renal development. (C) 1996 Wiley-Liss, Inc.

Close

Details

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalGenes, Chromosomes and Cancer
Volume17
Issue number3
DOIs
Publication statusPublished - Nov 1996

    Research areas

  • LOCUS, GENE, HETEROZYGOSITY, CHROMOSOME-11, CONSTRUCTION, FEATURES, CANCER, KIDNEY

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031

    Sarr, A., Bré, J., Um, I. H., Chan, T. H., Mullen, P., Harrison, D. J. & Reynolds, P. A., 21 May 2019, In : Scientific Reports. 9, 13 p., 7643.

    Research output: Contribution to journalArticle

  2. Glutaminase inhibition in renal cell carcinoma therapy

    Raczka, A. M. & Reynolds, P. A., 14 May 2019, In : Cancer Drug Resistance. 2, 9 p.

    Research output: Contribution to journalReview article

  3. Podocyte injury elicits loss and recovery of cellular forces

    Haley, K., Kronenberg, N. M., Liehm, P., Elshani, M., Bell, C., Harrison, D. J., Gather, M. C. & Reynolds, P. A., 27 Jun 2018, In : Science Advances. 4, 6, 9 p., eaap8030.

    Research output: Contribution to journalArticle

  4. Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells

    Tilston-Lunel, A. M., Haley, K., Schlecht, N., Wang, Y., Chatterton, A. L. D., Moleirinho, S. L., Watson, A., Hundal, H., Prystowsky, M., Gunn-Moore, F. J. & Reynolds, P. A., Oct 2016, In : Journal of Molecular Cell Biology. 8, 5, p. 439-455

    Research output: Contribution to journalArticle

  5. Willing to be involved in cancer

    Gunn-Moore, F. J., Tilston-Lunel, A. M. & Reynolds, P. A., 18 Jul 2016, In : Genes. 7, 7, 13 p., 37.

    Research output: Contribution to journalReview article

Related by journal

  1. Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death.

    Pettigrew, K. A., Armstrong, R., Colyer, H., Zhang, S-D., Rea, I. M., Jones, R., Baird, D. & Mills, K., Aug 2012, In : Genes, Chromosomes and Cancer. 51, 8, p. 768-780 13 p., 51(8).

    Research output: Contribution to journalArticle

  2. Gene amplification of atypical PKC-binding PARD3 in raditation-transformed neoplastic retinal pigment epithelial cell lines

    Zitzelsberger, H., Hieber, L., Richter, H., Unger, K., Briscoe, CV., Peddie, C. & Riches, A. C., May 2004, In : Genes, Chromosomes and Cancer. 40, 1, p. 55-59 5 p.

    Research output: Contribution to journalArticle

ID: 384113

Top