Skip to content

Research at St Andrews

Management of multidrug-resistant TB: novel treatments and their expansion to low resource settings

Research output: Contribution to journalReview article

DOI

Open Access permissions

Open

Author(s)

Derek James Sloan, Joseph M. Lewis

School/Research organisations

Abstract

Despite overall progress in global TB control, the rising burden ofmultidrug-resistant TB (MDR-TB) threatens to undermine efforts to end theworldwide epidemic. Of the 27 countries classified as high burden for MDR-TB, 17 are in 'low' or 'low-middle' income countries. Shorter, all oral and less toxic multidrug combinations are required to improve treatment outcomes in these settings. Suitability for safe co-administration with HIV drugs is also desirable. A range of strategies and several new drugs (including bedaquiline, delamanid and linezolid) are currently undergoing advanced clinical evaluations to define their roles in achieving these aims. However, several clinical questions and logistical challenges need to be overcome before these new MDR-TB treatments fulfil their potential.

Close

Details

Original languageEnglish
Article numbertrv107
Pages (from-to)163-172
Number of pages10
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume110
Issue number3
DOIs
Publication statusPublished - Mar 2016

    Research areas

  • Bedaquiline, Delamanid, Extensively drug-resistant, Linezolid, Multidrug-resistant, Tuberculosis

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. A tuberculosis molecular bacterial load assay (TB-MBLA)

    Sabiiti, W., Mtafya, B. A., Alferes De Lima, D., Dombay, E., Baron, V. O., Azam, K., Orascova, K., Sloan, D. J. & Gillespie, S. H., 6 Sep 2019, (Accepted/In press) In : Journal of Visualized Experiments.

    Research output: Contribution to journalArticle

  2. Protocol for the development of the STrengthening the Reporting of Pharmacogenetic Studies (STROPS) guideline: checklist of items for reporting pharmacogenetic studies

    Richardson, M., Kirkham, J. J., Dwan, K. M., Sloan, D. J., Davies, G. & Jorgensen, A., 11 Jul 2019, In : BMJ Open. 9, 7, 5 p., e030212.

    Research output: Contribution to journalArticle

  3. Linezolid for drug-resistant pulmonary tuberculosis

    Singh, B., Cocker, D., Ryan, H. & Sloan, D. J., 20 Mar 2019, In : Cochrane Database of Systematic Reviews. 2019, 3, CD012836.

    Research output: Contribution to journalReview article

  4. Evaluation of the efficacy of two methods for direct extraction of DNA from Mycobacterium tuberculosis sputum

    Ndhlovu, V., Mandala, W., Sloan, D., Kamdolozi, M., Caws, M. & Davies, G., 31 Dec 2018, In : Journal of Infection in Developing Countries. 12, 12, p. 1067-1072 6 p.

    Research output: Contribution to journalArticle

  5. Effect of the duration of antimicrobial exposure on the development of antimicrobial resistance (AMR) for macrolide antibiotics: protocol for a systematic review with a network meta-analysis

    Divala, T. H., Corbett, E. L., Stagg, H. R., Nliwasa, M., Sloan, D. J., French, N. & Fielding, K. L., 23 Dec 2018, In : Systematic Reviews. 7, 9 p., 246.

    Research output: Contribution to journalArticle

Related by journal

  1. Detection of malaria in Malaysia by nested polymerase chain reaction amplification of dried blood spots on filter papers

    Singh, B., Cox-Singh, J., Miller, A. O., Abdullah, M. S., Snounou, G. & Rahman, H. A., 1996, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 90, 5, p. 519-521 3 p.

    Research output: Contribution to journalArticle

  2. Nutritional status and weight gain in patients with pulmonary tuberculosis in Tanzania

    Kennedy, Uiso, L., Gutmann, J., Ngowi, F. I. & Gillespie, S. H., 1 Jan 1996, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 90, 2, p. 162-166 5 p.

    Research output: Contribution to journalArticle

  3. Restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis in northern Tanzania

    Gillespie, S. H., Kennedy, N., Ngowi, F. I., Fomukong, N. G., Al-Maamary, S. & Dale, J. W., 1 Jan 1995, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 89, 3, p. 335-338 4 p.

    Research output: Contribution to journalArticle

ID: 241920865

Top