Skip to content

Research at St Andrews

Mechanisms of infection by the human fungal pathogen Cryptococcus neoformans

Research output: Contribution to journalArticle

DOI

Author(s)

Wilber Sabiiti, Robin C May

School/Research organisations

Abstract

Brain infection by the fungus Cryptococcus neoformans results in inflammation of the meninges and brain parenchyma, a condition known as meningoencephalitis. One million people are estimated to suffer cryptococcal meningitis globally and >60% of these cases die within 3 months of diagnosis. Humans are believed to contract infection by inhalation of spores or dried yeast cells, which subsequently colonize the lung tissue. In the lungs, cryptococci may be cleared by the lung phagocytes, stay latent, cause pulmonary infection and/or disseminate to other body parts, preferentially the brain, culminating in cryptococcal meningoencephalitis. In this review, we discuss the pathogenesis of C. neoformans from the environment to the brain, the current understanding of the mechanisms of cryptococcal transmission into the brain and cryptococcal meningitis. We also give an insight into future cryptococcosis research and the development of novel therapies.
Close

Details

Original languageEnglish
Pages (from-to)1297-313
Number of pages17
JournalFuture Microbiology
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 2012

    Research areas

  • Blood-Brain Barrier, Cryptococcus neoformans, Humans, Lung Diseases, Fungal, Meningitis, Cryptococcal, Spores, Fungal

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. A tuberculosis molecular bacterial load assay (TB-MBLA)

    Sabiiti, W., Mtafya, B. A., Alferes De Lima, D., Dombay, E., Baron, V. O., Azam, K., Orascova, K., Sloan, D. J. & Gillespie, S. H., 6 Sep 2019, (Accepted/In press) In : Journal of Visualized Experiments.

    Research output: Contribution to journalArticle

  2. Model-based relationship between the molecular bacterial load assay and time-to-positivity in liquid culture

    Svensson, R. J., Sabiiti, W., Kibiki, G. S., Ntinginya, N. E., Bhatt, N., Davies, G., Gillespie, S. H. & Simonsson, U. S. H., 29 Jul 2019, In : Antimicrobial Agents and Chemotherapy. Early

    Research output: Contribution to journalArticle

  3. Molecular bacterial load assay (MBLA) concurs with culture on the NaOH-induced Mycobacterium tuberculosis loss of viability

    Mtafya, B., Sabiiti, W., Sabi, I., John, J., Sichone, E., Ntinginya, N. E. & Gillespie, S. H., 25 Jun 2019, In : Journal of Clinical Microbiology. 57, e01992-18.

    Research output: Contribution to journalArticle

  4. Heat-inactivation renders sputum safe and preserves Mycobacterium tuberculosis RNA for downstream molecular tests

    Sabiiti, W., Azam, K., Esmeraldo, E., Bhatt, N., Rachow, A. & Gillespie, S. H., Mar 2019, In : Journal of Clinical Microbiology. 57, 4, 8 p., e01778-18.

    Research output: Contribution to journalArticle

Related by journal

  1. A pilot experience of common European infectious diseases curriculum for medical students: the IDEAL summer school

    Charlier, C., Wolf, F. I., Vlieghe, E., Planquette, B., Van Damme, P., de Gaetano, K., Buffet, P., Henry, B., Cevik, M., Leen, C., Laurenson, I., Cameron, H., Ogavu, J., Nabankema, E., Omona, V., Valnaud, P., Mackintosh, C., Johannessen, I., Van Geertruyden, J-P., Le Jeunne, C. & 1 others, Cauda, R., Mar 2019, In : Future Microbiology. 14, 5, p. 369-372 4 p.

    Research output: Contribution to journalArticle

  2. Malaria: what can apes teach humans?

    Cox-Singh, J. & Cox Singh, J., Aug 2010, In : Future Microbiology. 5, 8, p. 1157-1160 4 p.

    Research output: Contribution to journalEditorial

ID: 199048640

Top