Skip to content

Research at St Andrews

University > Research portal > Research publications > Mechanistic development and recent applications of the Chan–...

Mechanistic development and recent applications of the Chan–Lam amination

Research output: Contribution to journal › Review article › peer-review

DOI

Open Access permissions

Open

Links

Author(s)

Matthew West, James Fyfe, Julien C. Vantourout, Allan J. B. Watson

School/Research organisations

Abstract

Transition metal-mediated formation of C–N bonds is an essential synthetic methodology. The discovery of the Chan–Lam amination provided a C–N bond forming process that was mild, convenient, and inexpensive, offering an alternative to complementary methods using other transition metals (TMs). Over the past 20 years, this reaction has seen considerable development in its scope of application, uptake into industry, and understanding of its mechanism. This review provides an account of the development of the Chan–Lam amination, highlighting progress and notable examples of application since 2011. Focus is given to evolution in mechanistic understanding and selected applications of the methodology within medicinal and process chemistry.
Close
More...

Details

Original languageEnglish
JournalChemical Reviews
VolumeArticles ASAP
Early online date22 Nov 2019
DOIs
Publication statusE-pub ahead of print - 22 Nov 2019

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Cu(OTf)2-mediated cross-coupling of nitriles and N-heterocycles with arylboronic acids to generate nitrilium and pyridinium products

    Bell, N., Xu, C., Fyfe, J., Vantourout, J. C., Brals, J., Chabbra, S., Bode, B. E., Cordes, D. B., Slawin, A. M. Z., McGuire, T. M. & Watson, A. J. B., 26 Feb 2021, In: Angewandte Chemie International Edition. Early View, 7 p.

    Research output: Contribution to journal › Article › peer-review

  2. In vivo half-life extension of BMP1/TLL metalloproteinase inhibitors using small-molecule human serum albumin binders

    Vantourout, J. C., Mason, A. M., Yuen, J., Simpson, G. L., Evindar, G., Kuai, L., Hobbs, M., Edgar, E., Needle, S., Bai, X., Wilson, S., Scott-Stevens, P., Traylen, W., Lambert, K., Young, N., Bunally, S., Summerfield, S. G., Snell, R., Lad, R., Shi, E. & 13 others, Skinner, S., Shewchuk, L., Watson, A. J. B., Chung, C-W., Pal, S., Holt, D. A., Kallander, L. S., Prendergast, J., Rivera, K., Washburn, D. G., Harpel, M. R., Arico-Muendel, C. & Isidro-Llobet, A., 17 Feb 2021, In: Bioconjugate Chemistry. 32, 2

    Research output: Contribution to journal › Article › peer-review

  3. First experimental evidence for a bis-ethene chromium(I) complex forming from an activated ethene oligomerization catalyst

    Chabbra, S., Smith, D. M., Bell, N. L., Watson, A. J. B., Buehl, M., Cole-Hamilton, D. J. & Bode, B. E., 18 Dec 2020, In: Science Advances. 6, 51, 7 p., eabd7057.

    Research output: Contribution to journal › Article › peer-review

  4. Catalytic enantioselective synthesis of heterocyclic vicinal fluoroamines using asymmetric protonation: a method development and mechanistic study

    Ashford, M., Xu, C., Molloy, J. J., Carpenter-Warren, C. L., Slawin, A. M. Z., Leach, A. G. & Watson, A. J. B., 21 Sep 2020, In: Chemistry - A European Journal. 26, 53, p. 12249-12255 8 p.

    Research output: Contribution to journal › Article › peer-review

  5. Deoxyfluorination using CuF2: enabled by a Lewis base activating group strategy

    Sood, D. E., Champion, S., Dawson, D. M., Chabbra, S., Bode, B. E., Sutherland, A. C. & Watson, A. J. B., 18 May 2020, In: Angewandte Chemie International Edition. 55, 22, p. 8460-8463

    Research output: Contribution to journal › Article › peer-review

Related by journal

  1. Angle, spin, and depth resolved photoelectron spectroscopy on quantum materials

    King, P. D. C., Picozzi, S., Egdell, R. & Panaccione, G., 21 Dec 2020, In: Chemical Reviews. Articles ASAP, 41 p.

    Research output: Contribution to journal › Review article › peer-review

  2. A hierarchical nanoporous diamondoid superstructure

    Guo, Q. H., Liu, Z., Li, P., Shen, D., Xu, Y., Ryder, M. R., Chen, H., Stern, C. L., Malliakas, C. D., Zhang, X., Zhang, L., Qiu, Y., Shi, Y., Snurr, R. Q., Philp, D., Farha, O. K. & Stoddart, J. F., 12 Sep 2019, In: Chem. 5, 9, p. 2353-2364 12 p.

    Research output: Contribution to journal › Article › peer-review

  3. Light harvesting for organic photovoltaics

    Hedley, G. J., Ruseckas, A. & Samuel, I. D. W., 25 Jan 2017, In: Chemical Reviews. 117, 2, p. 796-837 42 p.

    Research output: Contribution to journal › Review article › peer-review

  4. Recent developments in organoboron chemistry - old dogs, new tricks

    Fyfe, J. W. B. & Watson, A. J. B., 13 Jul 2017, In: Chemical Reviews. 3, 1, p. 31-55 5 p.

    Research output: Contribution to journal › Review article › peer-review

ID: 263441530

Top