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Memory versus effector immune responses in oncolytic virotherapies

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Memory versus effector immune responses in oncolytic virotherapies. / Macnamara, Cicely Krystyna; Eftimie, Raluca.

In: Journal of Theoretical Biology, Vol. 377, 21.07.2015, p. 1-9.

Research output: Contribution to journalArticlepeer-review

Harvard

Macnamara, CK & Eftimie, R 2015, 'Memory versus effector immune responses in oncolytic virotherapies', Journal of Theoretical Biology, vol. 377, pp. 1-9. https://doi.org/10.1016/j.jtbi.2015.04.004

APA

Macnamara, C. K., & Eftimie, R. (2015). Memory versus effector immune responses in oncolytic virotherapies. Journal of Theoretical Biology, 377, 1-9. https://doi.org/10.1016/j.jtbi.2015.04.004

Vancouver

Macnamara CK, Eftimie R. Memory versus effector immune responses in oncolytic virotherapies. Journal of Theoretical Biology. 2015 Jul 21;377:1-9. https://doi.org/10.1016/j.jtbi.2015.04.004

Author

Macnamara, Cicely Krystyna ; Eftimie, Raluca. / Memory versus effector immune responses in oncolytic virotherapies. In: Journal of Theoretical Biology. 2015 ; Vol. 377. pp. 1-9.

Bibtex - Download

@article{3a1184d85030451e946b79eba3f8720d,
title = "Memory versus effector immune responses in oncolytic virotherapies",
abstract = "The main priority when designing cancer immuno-therapies has been toseek viable biological mechanisms that lead to permanent cancer eradicationor cancer control. Understanding the delicate balance between the roleof effector and memory cells on eliminating cancer cells remains an elusiveproblem in immunology. Here we make an initial investigation into thisproblem with the help of a mathematical model for oncolytic virotherapy;although the model can in fact be made general enough to be applied also toother immunological problems. Our results show that long-term cancer controlis associated with a large number of persistent effector cells (irrespectiveof the initial peak in effector cell numbers). However, this large number ofpersistent effector cells is sustained by a relatively large number of memorycells. Moreover, we show that cancer control from a dormant state cannotbe predicted by the size of the memory population.",
keywords = "Cancer modelling, Effector and memory cells, Tumour control, Cancer dormancy",
author = "Macnamara, {Cicely Krystyna} and Raluca Eftimie",
note = "R.E. acknowledges support from an Engineering and Physical Sciences Research Council (UK) First Grant number EP/K033689/1",
year = "2015",
month = jul,
day = "21",
doi = "10.1016/j.jtbi.2015.04.004",
language = "English",
volume = "377",
pages = "1--9",
journal = "Journal of Theoretical Biology",
issn = "0022-5193",
publisher = "ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Memory versus effector immune responses in oncolytic virotherapies

AU - Macnamara, Cicely Krystyna

AU - Eftimie, Raluca

N1 - R.E. acknowledges support from an Engineering and Physical Sciences Research Council (UK) First Grant number EP/K033689/1

PY - 2015/7/21

Y1 - 2015/7/21

N2 - The main priority when designing cancer immuno-therapies has been toseek viable biological mechanisms that lead to permanent cancer eradicationor cancer control. Understanding the delicate balance between the roleof effector and memory cells on eliminating cancer cells remains an elusiveproblem in immunology. Here we make an initial investigation into thisproblem with the help of a mathematical model for oncolytic virotherapy;although the model can in fact be made general enough to be applied also toother immunological problems. Our results show that long-term cancer controlis associated with a large number of persistent effector cells (irrespectiveof the initial peak in effector cell numbers). However, this large number ofpersistent effector cells is sustained by a relatively large number of memorycells. Moreover, we show that cancer control from a dormant state cannotbe predicted by the size of the memory population.

AB - The main priority when designing cancer immuno-therapies has been toseek viable biological mechanisms that lead to permanent cancer eradicationor cancer control. Understanding the delicate balance between the roleof effector and memory cells on eliminating cancer cells remains an elusiveproblem in immunology. Here we make an initial investigation into thisproblem with the help of a mathematical model for oncolytic virotherapy;although the model can in fact be made general enough to be applied also toother immunological problems. Our results show that long-term cancer controlis associated with a large number of persistent effector cells (irrespectiveof the initial peak in effector cell numbers). However, this large number ofpersistent effector cells is sustained by a relatively large number of memorycells. Moreover, we show that cancer control from a dormant state cannotbe predicted by the size of the memory population.

KW - Cancer modelling

KW - Effector and memory cells

KW - Tumour control

KW - Cancer dormancy

U2 - 10.1016/j.jtbi.2015.04.004

DO - 10.1016/j.jtbi.2015.04.004

M3 - Article

VL - 377

SP - 1

EP - 9

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

SN - 0022-5193

ER -

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