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Metal-ligand cooperation facilitates bond activation and catalytic hydrogenation with zinc pincer complexes

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Author(s)

Michael Rauch, Sayan Kar, Amit Kumar, Liat Avram, Linda J W Shimon, David Milstein

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Abstract

A series of PNP zinc pincer complexes capable of bond activation via aromatization/dearomatization metal-ligand cooperation (MLC) were prepared and characterized. Reversible heterolytic N-H and H-H bond activation by MLC is shown, in which hemilability of the phosphorus linkers plays a key role. Utilizing this zinc pincer system, base-free catalytic hydrogenation of imines and ketones under relatively mild conditions is demonstrated. A detailed mechanistic study supported by computation implicates the key role of MLC in facili-tating effective catalysis. This approach offers a new strategy for (de)hydrogenation and other catalytic transformations mediated by zinc and other main group metals.
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Original languageEnglish
Pages (from-to)14513-14521
JournalJournal of the American Chemical Society
Volume142
Issue number34
Early online date28 Jul 2020
DOIs
Publication statusPublished - 26 Aug 2020

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