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Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

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Author(s)

Marcel Schubert, Lewis Woolfson, Isla R.M. Barnard, Andrew Morton, Becky Casement, Gavin B. Robertson, Gareth B. Miles, Samantha J. Pitt, Carl S. Tucker, Malte C. Gather

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Abstract

Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.

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Original languageEnglish
Title of host publicationNovel biophotonics techniques and applications V
EditorsArjen Amelink, Seemantini K. Nadkarni
PublisherSPIE
Number of pages3
ISBN (Electronic)9781510628434
DOIs
Publication statusPublished - 22 Jul 2019
EventEuropean Conferences on Biomedical Optics - Munich, Germany
Duration: 23 Jun 2019 → 27 Jun 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11075
ISSN (Print)1605-7422

Conference

ConferenceEuropean Conferences on Biomedical Optics
CountryGermany
CityMunich
Period23/06/19 → 27/06/19

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    Schubert, M., Woolfson, L., Barnard, I. R. M., Dorward, A., Casement, B., Morton, A., Robertson, G. B., Appleton, P. L., Miles, G. B., Tucker, C. S., Pitt, S. J. & Gather, M. C., Jul 2020, In: Nature Photonics. 14, 7, p. 452–458 12 p.

    Research output: Contribution to journal › Article › peer-review

  2. Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

    Schubert, M., Woolfson, L., Barnard, I. R. M., Morton, A., Casement, B., Robertson, G. B., Miles, G. B., Pitt, S. J., Tucker, C. S. & Gather, M. C., 8 Apr 2019, Novel Techniques in Microscopy - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP). Optical Society of American (OSA), NM4C.2. (Novel Techniques in Microscopy - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP)).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  3. Lasing in live mitotic and non-phagocytic cells by efficient delivery of microresonators

    Schubert, M., Volckaert, K., Karl, M., Morton, A., Liehm, P., Miles, G. B., Powis, S. J. & Gather, M. C., 19 Jan 2017, In: Scientific Reports. 7, 40877.

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  4. Photostimulation for in vitro optogenetics with high power blue organic light-emitting diodes

    Morton, A., Murawski, C., Deng, Y., Keum, C., Miles, G. B., Tello, J. A. & Gather, M. C., 18 Mar 2019, In: Advanced Biosystems. 3, 3, 8 p., 1800290.

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  5. Distributed feedback lasers based on green fluorescent protein and conformal high refractive index oxide layers

    Karl, M., Meek, A. T., Murawski, C., Tropf, L. C., Keum, C., Schubert, M., Samuel, I. D. W., Turnbull, G. A. & Gather, M. C., Jun 2020, In: Laser & Photonics Reviews. 14, 6, 7 p., 2000101.

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ID: 263664849

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