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Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

DOI

Author(s)

Marcel Schubert, Lewis Woolfson, Isla R.M. Barnard, Andrew Morton, Becky Casement, Gavin B. Robertson, Gareth B. Miles, Samantha J. Pitt, Carl S. Tucker, Malte C. Gather

School/Research organisations

Abstract

Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.

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Details

Original languageEnglish
Title of host publicationNovel Techniques in Microscopy - Proceedings Biophotonics Congress
Subtitle of host publicationOptics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP)
PublisherOptical Society of American (OSA)
ISBN (Electronic)9781943580545
DOIs
Publication statusPublished - 8 Apr 2019
EventNovel Techniques in Microscopy, NTM 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019 - Tucson, United States
Duration: 14 Apr 2019 → 17 Apr 2019

Publication series

NameNovel Techniques in Microscopy - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP)

Conference

ConferenceNovel Techniques in Microscopy, NTM 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019
CountryUnited States
CityTucson
Period14/04/19 → 17/04/19

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    Schubert, M., Woolfson, L., Barnard, I. R. M., Dorward, A., Casement, B., Morton, A., Robertson, G. B., Appleton, P. L., Miles, G. B., Tucker, C. S., Pitt, S. J. & Gather, M. C., Jul 2020, In: Nature Photonics. 14, 7, p. 452–458 12 p.

    Research output: Contribution to journal › Article › peer-review

  2. Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

    Schubert, M., Woolfson, L., Barnard, I. R. M., Morton, A., Casement, B., Robertson, G. B., Miles, G. B., Pitt, S. J., Tucker, C. S. & Gather, M. C., 22 Jul 2019, Novel biophotonics techniques and applications V. Amelink, A. & Nadkarni, S. K. (eds.). SPIE, 3 p. 110750C. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11075).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  3. Lasing in live mitotic and non-phagocytic cells by efficient delivery of microresonators

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  4. Photostimulation for in vitro optogenetics with high power blue organic light-emitting diodes

    Morton, A., Murawski, C., Deng, Y., Keum, C., Miles, G. B., Tello, J. A. & Gather, M. C., 18 Mar 2019, In: Advanced Biosystems. 3, 3, 8 p., 1800290.

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  5. Distributed feedback lasers based on green fluorescent protein and conformal high refractive index oxide layers

    Karl, M., Meek, A. T., Murawski, C., Tropf, L. C., Keum, C., Schubert, M., Samuel, I. D. W., Turnbull, G. A. & Gather, M. C., Jun 2020, In: Laser & Photonics Reviews. 14, 6, 7 p., 2000101.

    Research output: Contribution to journal › Review article › peer-review

ID: 271389522

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