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Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: Biological insights from a hybrid multiscale cellular automaton model

Research output: Contribution to journalArticlepeer-review

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Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy : Biological insights from a hybrid multiscale cellular automaton model. / Powathil, G.G.; Gordon, K.E.; Hill, L.A.; Chaplain, M.A.J.

In: Journal of Theoretical Biology, Vol. 308, 01.01.2012, p. 1-19.

Research output: Contribution to journalArticlepeer-review

Harvard

Powathil, GG, Gordon, KE, Hill, LA & Chaplain, MAJ 2012, 'Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: Biological insights from a hybrid multiscale cellular automaton model', Journal of Theoretical Biology, vol. 308, pp. 1-19. https://doi.org/10.1016/j.jtbi.2012.05.015

APA

Powathil, G. G., Gordon, K. E., Hill, L. A., & Chaplain, M. A. J. (2012). Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: Biological insights from a hybrid multiscale cellular automaton model. Journal of Theoretical Biology, 308, 1-19. https://doi.org/10.1016/j.jtbi.2012.05.015

Vancouver

Powathil GG, Gordon KE, Hill LA, Chaplain MAJ. Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: Biological insights from a hybrid multiscale cellular automaton model. Journal of Theoretical Biology. 2012 Jan 1;308:1-19. https://doi.org/10.1016/j.jtbi.2012.05.015

Author

Powathil, G.G. ; Gordon, K.E. ; Hill, L.A. ; Chaplain, M.A.J. / Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy : Biological insights from a hybrid multiscale cellular automaton model. In: Journal of Theoretical Biology. 2012 ; Vol. 308. pp. 1-19.

Bibtex - Download

@article{36cc202be0a6432ba0bc2146d2de10c4,
title = "Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: Biological insights from a hybrid multiscale cellular automaton model",
abstract = "The therapeutic control of a solid tumour depends critically on the responses of the individual cells that constitute the entire tumour mass. A particular cell's spatial location within the tumour and intracellular interactions, including the evolution of the cell-cycle within each cell, has an impact on their decision to grow and divide. They are also influenced by external signals from other cells as well as oxygen and nutrient concentrations. Hence, it is important to take these into account when modelling tumour growth and the response to various treatment regimes ('cell-kill therapies'), including chemotherapy.In order to address this multiscale nature of solid tumour growth and its response to treatment, we propose a hybrid, individual-based approach that analyses spatio-temporal dynamics at the level of cells, linking individual cell behaviour with the macroscopic behaviour of cell organisation and the microenvironment. The individual tumour cells are modelled by using a cellular automaton (CA) approach, where each cell has its own internal cell-cycle, modelled using a system of ODEs. The internal cell-cycle dynamics determine the growth strategy in the CA model, making it more predictive and biologically relevant. It also helps to classify the cells according to their cell-cycle states and to analyse the effect of various cell-cycle dependent cytotoxic drugs. Moreover, we have incorporated the evolution of oxygen dynamics within this hybrid model in order to study the effects of the microenvironment in cell-cycle regulation and tumour treatments. An important factor from the treatment point of view is that the low concentration of oxygen can result in a hypoxia-induced quiescence (G0/G1 arrest) of the cancer cells, making them resistant to key cytotoxic drugs. Using this multiscale model, we investigate the impact of oxygen heterogeneity on the spatio-temporal patterning of the cell distribution and their cell-cycle status. We demonstrate that oxygen transport limitations result in significant heterogeneity in HIF-1 a signalling and cell-cycle status, and when these are combined with drug transport limitations, the efficacy of the therapy is significantly impaired. {\textcopyright} 2012 Elsevier Ltd.",
author = "G.G. Powathil and K.E. Gordon and L.A. Hill and M.A.J. Chaplain",
year = "2012",
month = jan,
day = "1",
doi = "10.1016/j.jtbi.2012.05.015",
language = "English",
volume = "308",
pages = "1--19",
journal = "Journal of Theoretical Biology",
issn = "0022-5193",
publisher = "ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy

T2 - Biological insights from a hybrid multiscale cellular automaton model

AU - Powathil, G.G.

AU - Gordon, K.E.

AU - Hill, L.A.

AU - Chaplain, M.A.J.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - The therapeutic control of a solid tumour depends critically on the responses of the individual cells that constitute the entire tumour mass. A particular cell's spatial location within the tumour and intracellular interactions, including the evolution of the cell-cycle within each cell, has an impact on their decision to grow and divide. They are also influenced by external signals from other cells as well as oxygen and nutrient concentrations. Hence, it is important to take these into account when modelling tumour growth and the response to various treatment regimes ('cell-kill therapies'), including chemotherapy.In order to address this multiscale nature of solid tumour growth and its response to treatment, we propose a hybrid, individual-based approach that analyses spatio-temporal dynamics at the level of cells, linking individual cell behaviour with the macroscopic behaviour of cell organisation and the microenvironment. The individual tumour cells are modelled by using a cellular automaton (CA) approach, where each cell has its own internal cell-cycle, modelled using a system of ODEs. The internal cell-cycle dynamics determine the growth strategy in the CA model, making it more predictive and biologically relevant. It also helps to classify the cells according to their cell-cycle states and to analyse the effect of various cell-cycle dependent cytotoxic drugs. Moreover, we have incorporated the evolution of oxygen dynamics within this hybrid model in order to study the effects of the microenvironment in cell-cycle regulation and tumour treatments. An important factor from the treatment point of view is that the low concentration of oxygen can result in a hypoxia-induced quiescence (G0/G1 arrest) of the cancer cells, making them resistant to key cytotoxic drugs. Using this multiscale model, we investigate the impact of oxygen heterogeneity on the spatio-temporal patterning of the cell distribution and their cell-cycle status. We demonstrate that oxygen transport limitations result in significant heterogeneity in HIF-1 a signalling and cell-cycle status, and when these are combined with drug transport limitations, the efficacy of the therapy is significantly impaired. © 2012 Elsevier Ltd.

AB - The therapeutic control of a solid tumour depends critically on the responses of the individual cells that constitute the entire tumour mass. A particular cell's spatial location within the tumour and intracellular interactions, including the evolution of the cell-cycle within each cell, has an impact on their decision to grow and divide. They are also influenced by external signals from other cells as well as oxygen and nutrient concentrations. Hence, it is important to take these into account when modelling tumour growth and the response to various treatment regimes ('cell-kill therapies'), including chemotherapy.In order to address this multiscale nature of solid tumour growth and its response to treatment, we propose a hybrid, individual-based approach that analyses spatio-temporal dynamics at the level of cells, linking individual cell behaviour with the macroscopic behaviour of cell organisation and the microenvironment. The individual tumour cells are modelled by using a cellular automaton (CA) approach, where each cell has its own internal cell-cycle, modelled using a system of ODEs. The internal cell-cycle dynamics determine the growth strategy in the CA model, making it more predictive and biologically relevant. It also helps to classify the cells according to their cell-cycle states and to analyse the effect of various cell-cycle dependent cytotoxic drugs. Moreover, we have incorporated the evolution of oxygen dynamics within this hybrid model in order to study the effects of the microenvironment in cell-cycle regulation and tumour treatments. An important factor from the treatment point of view is that the low concentration of oxygen can result in a hypoxia-induced quiescence (G0/G1 arrest) of the cancer cells, making them resistant to key cytotoxic drugs. Using this multiscale model, we investigate the impact of oxygen heterogeneity on the spatio-temporal patterning of the cell distribution and their cell-cycle status. We demonstrate that oxygen transport limitations result in significant heterogeneity in HIF-1 a signalling and cell-cycle status, and when these are combined with drug transport limitations, the efficacy of the therapy is significantly impaired. © 2012 Elsevier Ltd.

UR - http://www.scopus.com/inward/record.url?scp=84861994004&partnerID=8YFLogxK

U2 - 10.1016/j.jtbi.2012.05.015

DO - 10.1016/j.jtbi.2012.05.015

M3 - Article

VL - 308

SP - 1

EP - 19

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

SN - 0022-5193

ER -

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