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Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain

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Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. / Albuixech-Crespo, Beatriz; López-Blanch, Laura; Burguera, Demian; Maeso, Ignacio; Sánchez Arrones, Luisa; Moreno-Bravo, Juan Antonio; Somorjai, Ildiko; Pascual-Anaya, Juan; Puelles, Eduardo; Bovolenta, Paola; Garcia-Fernàndez, Jordi; Puelles, Luis; Irimia, Manuel; Ferran, José Luis.

In: PLoS Biology, Vol. 15, No. 4, e2001573, 19.04.2017.

Research output: Contribution to journalArticle

Harvard

Albuixech-Crespo, B, López-Blanch, L, Burguera, D, Maeso, I, Sánchez Arrones, L, Moreno-Bravo, JA, Somorjai, I, Pascual-Anaya, J, Puelles, E, Bovolenta, P, Garcia-Fernàndez, J, Puelles, L, Irimia, M & Ferran, JL 2017, 'Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain' PLoS Biology, vol. 15, no. 4, e2001573. https://doi.org/10.1371/journal.pbio.2001573

APA

Albuixech-Crespo, B., López-Blanch, L., Burguera, D., Maeso, I., Sánchez Arrones, L., Moreno-Bravo, J. A., ... Ferran, J. L. (2017). Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biology, 15(4), [e2001573]. https://doi.org/10.1371/journal.pbio.2001573

Vancouver

Albuixech-Crespo B, López-Blanch L, Burguera D, Maeso I, Sánchez Arrones L, Moreno-Bravo JA et al. Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biology. 2017 Apr 19;15(4). e2001573. https://doi.org/10.1371/journal.pbio.2001573

Author

Albuixech-Crespo, Beatriz ; López-Blanch, Laura ; Burguera, Demian ; Maeso, Ignacio ; Sánchez Arrones, Luisa ; Moreno-Bravo, Juan Antonio ; Somorjai, Ildiko ; Pascual-Anaya, Juan ; Puelles, Eduardo ; Bovolenta, Paola ; Garcia-Fernàndez, Jordi ; Puelles, Luis ; Irimia, Manuel ; Ferran, José Luis. / Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. In: PLoS Biology. 2017 ; Vol. 15, No. 4.

Bibtex - Download

@article{0304eab758534324a6b1984583849dec,
title = "Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain",
abstract = "All vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative expression of 48 genes with key roles in vertebrate neural patterning in a representative amphioxus embryonic stage. Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topological comparisons. The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions. Strikingly, comparison with vertebrates indicates that the vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region, which we termed Di-Mesencephalic primordium (DiMes). This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice.",
author = "Beatriz Albuixech-Crespo and Laura L{\'o}pez-Blanch and Demian Burguera and Ignacio Maeso and {S{\'a}nchez Arrones}, Luisa and Moreno-Bravo, {Juan Antonio} and Ildiko Somorjai and Juan Pascual-Anaya and Eduardo Puelles and Paola Bovolenta and Jordi Garcia-Fern{\`a}ndez and Luis Puelles and Manuel Irimia and Ferran, {Jos{\'e} Luis}",
note = "Funding: Marine Alliance for Science and Technology Scotland (MASTS).",
year = "2017",
month = "4",
day = "19",
doi = "10.1371/journal.pbio.2001573",
language = "English",
volume = "15",
journal = "PLoS Biology",
issn = "1544-9173",
publisher = "Public Library of Science",
number = "4",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain

AU - Albuixech-Crespo, Beatriz

AU - López-Blanch, Laura

AU - Burguera, Demian

AU - Maeso, Ignacio

AU - Sánchez Arrones, Luisa

AU - Moreno-Bravo, Juan Antonio

AU - Somorjai, Ildiko

AU - Pascual-Anaya, Juan

AU - Puelles, Eduardo

AU - Bovolenta, Paola

AU - Garcia-Fernàndez, Jordi

AU - Puelles, Luis

AU - Irimia, Manuel

AU - Ferran, José Luis

N1 - Funding: Marine Alliance for Science and Technology Scotland (MASTS).

PY - 2017/4/19

Y1 - 2017/4/19

N2 - All vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative expression of 48 genes with key roles in vertebrate neural patterning in a representative amphioxus embryonic stage. Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topological comparisons. The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions. Strikingly, comparison with vertebrates indicates that the vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region, which we termed Di-Mesencephalic primordium (DiMes). This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice.

AB - All vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative expression of 48 genes with key roles in vertebrate neural patterning in a representative amphioxus embryonic stage. Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topological comparisons. The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions. Strikingly, comparison with vertebrates indicates that the vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region, which we termed Di-Mesencephalic primordium (DiMes). This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice.

U2 - 10.1371/journal.pbio.2001573

DO - 10.1371/journal.pbio.2001573

M3 - Article

VL - 15

JO - PLoS Biology

T2 - PLoS Biology

JF - PLoS Biology

SN - 1544-9173

IS - 4

M1 - e2001573

ER -

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