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Multirate delivery of multiple therapeutic agents from metal-organic frameworks

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Author(s)

Alistair Craig McKinlay, Phoebe Allan, Catherine Louise Renouf, Morven Jane Duncan, Paul Stewart Wheatley, Stewart James Warrender, Daniel McLean Dawson, Sharon Elizabeth Marie Ashbrook, Barbara Gil, Bartosz Marszalek, Tina Düren, Jennifer J. Williams, Cedric Charrier, Derry K. Mercer, Simon J. Teat, Russell Edward Morris

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Abstract

The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.
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Original languageEnglish
Article number124108
JournalAPL Materials
Volume2
Issue number12
Early online date11 Dec 2014
DOIs
Publication statusPublished - Dec 2014

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