Skip to content

Research at St Andrews

Narrowband organic light-emitting diodes for fluorescence microscopy and calcium imaging

Research output: Contribution to journalArticle


Open Access Status

  • Embargoed (until 5/09/20)


Caroline Murawski, Andreas Mischok, Jonathan Hunter Booth, Jothi Dinesh Kumar, Emily Archer, Laura Christine Tropf, Changmin Keum, Yali Deng, Kou Yoshida, Ifor David William Samuel, Marcel Schubert, Stefan Pulver, Malte Christian Gather

School/Research organisations


Fluorescence imaging is an indispensable tool in biology, with applications ranging from single‐cell to whole‐animal studies and with live mapping of neuronal activity currently receiving particular attention. To enable fluorescence imaging at cellular scale in freely moving animals, miniaturized microscopes and lensless imagers are developed that can be implanted in a minimally invasive fashion; but the rigidity, size, and potential toxicity of the involved light sources remain a challenge. Here, narrowband organic light‐emitting diodes (OLEDs) are developed and used for fluorescence imaging of live cells and for mapping of neuronal activity in Drosophila melanogaster via genetically encoded Ca2+ indicators. In order to avoid spectral overlap with fluorescence from the sample, distributed Bragg reflectors are integrated onto the OLEDs to block their long‐wavelength emission tail, which enables an image contrast comparable to conventional, much bulkier mercury light sources. As OLEDs can be fabricated on mechanically flexible substrates and structured into arrays of cell‐sized pixels, this work opens a new pathway for the development of implantable light sources that enable functional imaging and sensing in freely moving animals.


Original languageEnglish
Number of pages8
JournalAdvanced Materials
VolumeEarly View
Early online date5 Sep 2019
Publication statusE-pub ahead of print - 5 Sep 2019

    Research areas

  • Calcium imaging, Distributed Bragg reflector, Fluorescence microscopy, OLED

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. The role of metallic dopants in improving the thermal stability of the electron transport layer in organic light-emitting diodes

    Keum, C-M., Kronenberg, N. M., Murawski, C., Yoshida, K., Deng, Y., Berz, C., Li, W., Wei, M., Samuel, I. D. W. & Gather, M. C., 25 Jun 2018, In : Advanced Optical Materials. Early View, 1800496.

    Research output: Contribution to journalArticle

  2. Flexible and ultra-lightweight polymer membrane lasers

    Karl, M., Glackin, J. M. E., Schubert, M., Kronenberg, N. M., Turnbull, G. A., Samuel, I. D. W. & Gather, M. C., 1 May 2018, In : Nature Communications. 9, 7 p., 1525.

    Research output: Contribution to journalArticle

  3. Time-resolved studies of energy transfer in thin films of green and red fluorescent proteins

    Zajac, J. M., Schubert, M., Roland, T., Keum, C., Samuel, I. D. W. & Gather, M. C., 15 Jan 2018, In : Advanced Functional Materials. Early View

    Research output: Contribution to journalArticle

  4. Single cell induced optical confinement in biological lasers

    Karl, M., Dietrich, C. P., Schubert, M., Samuel, I. D. W., Turnbull, G. A. & Gather, M. C., 1 Mar 2017, In : Journal of Physics D : Applied Physics. 50, 8, 9 p., 084005.

    Research output: Contribution to journalArticle

  5. Organic light-emitting diodes for optogenetic stimulation of Drosophila larvae

    Murawski, C., Morton, A., Samuel, I. D. W., Pulver, S. & Gather, M. C., 14 Nov 2016, Proceedings, Light, Energy and the Environment. Optical Society of American (OSA), 3 p. JW4A.9. (Fourier Transform Spectroscopy).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

Related by journal

  1. Advanced Materials (Journal)

    Finlay Morrison (Reviewer)
    2008 → …

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Related by journal

  1. An electronically-driven improper ferroelectric: tungsten bronzes as microstructural analogues for the hexagonal manganites

    McNulty, J. A., Tran, T. T., Halasyamani, P. S., McCartan, S., MacLaren, I., Gibbs, A., Lim, F., Turner, P., Gregg, J. M., Lightfoot, P. & Morrison, F. D., 4 Oct 2019, In : Advanced Materials. 31, 40, 1903620.

    Research output: Contribution to journalArticle

  2. Infrared organic light-emitting diodes with carbon nanotube emitters

    Graf, A., Murawski, C., Zakharko, Y., Zaumseil, J. & Gather, M. C., 22 Mar 2018, In : Advanced Materials. 30, 12, 1706711.

    Research output: Contribution to journalArticle

ID: 260667582