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Natural products incorporating pyrimidine nucleosides

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

Author(s)

Freideriki Michailidou, David Alexander Burnett, Sunil Vishnuprasadji Sharma, Steven Van Lanen, Rebecca Goss

School/Research organisations

Abstract

The uridyl peptide antibiotics are a class of structurally and biologically diverse series of pyrimidine containing natural products, that have attracted considerable interest due to their powerful and varied bioactivities; and potential for exploitation in human medicine as well as agriculture.

This article overviews the varied structures of the pyrimidine nucleoside-based antibiotics, their natural origins and their bioactivities. Current understanding of the enzyme mediated assemblies (biosynthesis) of these structurally intriguing compounds is overviewed.

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Details

Original languageEnglish
Title of host publicationReference module in chemistry, molecular sciences and chemical engineering
PublisherElsevier Inc.
ISBN (Print)9780124095472
DOIs
Publication statusE-pub ahead of print - 20 Feb 2020

    Research areas

  • Anti-microbial, Anti-tubercular, Anti-viral, Biosynthesis of UPAs, MraY, NRPS, Nucleoside antibiotics, Pyrimidine nucleosides, Uridyl peptide antibiotics (UPAs)

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