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NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy

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Author(s)

Sarah Fox, Tom S. Wilkinson, Paul S. Wheatley, Bo Xiao, Russell E. Morris, Alistair Sutherland, A. John Simpson, Peter G. Barlow, Anthony R. Butler, Ian L. Megson, Adriano G. Rossi

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Abstract

Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, defence against invading pathogens and wound healing. Transition metal exchanged zeolites are nanoporous materials with high-capacity storage properties for gases such as NO. The NO stores are liberated upon contact with aqueous environments, thereby making them ideal candidates for use in biological and clinical settings. Here, we demonstrate the NO release capacity and powerful bactericidal properties of a novel NO-storing Zn2+-exchanged zeolite material at a 50 wt.% composition in a polytetrafluoroethylene polymer. Further to our published data showing the anti-thrombotic effects of a similar NO-loaded zeolite, this study demonstrates the antibacterial properties of NO-releasing zeolites against clinically relevant strains of bacteria, namely Gram-negative Pseudomonas aeruginosa and Gram-positive methicillin-sensitive and methicillin-resistant Staphylococcus aureus and Clostridium difficile. Thus our study highlights the potential of NO-loaded zeolites as biocompatible medical device coatings with anti-infective properties. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

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Details

Original languageEnglish
Pages (from-to)1515-1521
Number of pages7
JournalActa Biomaterialia
Volume6
Issue number4
DOIs
Publication statusPublished - Apr 2010

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