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NO-Releasing Zeolites and Their Antithrombotic Properties

Research output: Contribution to journalArticle

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Author(s)

P.S. Wheately, A.R. Butler, M.S Crane, S Fox, B Xiao, A.G. Rossi, I.L. Megson, Russell Edward Morris

School/Research organisations

Abstract

Transition metal-exchanged zeolite-A adsorbs and stores nitric oxide in relatively high capacity (up to 1 mmol of NO/g of zeolite). The stored NO is released on contact with an aqueous environment under biologically relevant conditions of temperature and pH. The release of the NO can be tuned by altering the chemical composition of the zeolite, by controlling the amount of water contacting the zeolite, and by blending the zeolite with different polymers. The high capacity of zeolite for NO makes it extremely attractive for use in biological and medical applications, and our experiments indicate that the NO released from Co-exchanged zeolite-A inhibits platelet aggregation and adhesion of human platelets in vitro.

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Details

Original languageEnglish
Pages (from-to)502-509
Number of pages8
JournalJournal of the American Chemical Society
Volume128
Issue number2
DOIs
Publication statusPublished - 18 Jan 2006

    Research areas

  • NITRIC-OXIDE RELEASE, POLYMERIC FILMS, NITROGEN MONOXIDE, ADSORPTION, ENDOTHELIUM, COMPLEXES, STENTS, THROMBORESISTANT, DESORPTION, CATALYSTS

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