Skip to content

Research at St Andrews

NO-Releasing Zeolites and Their Antithrombotic Properties

Research output: Contribution to journalArticlepeer-review

DOI

Author(s)

P.S. Wheately, A.R. Butler, M.S Crane, S Fox, B Xiao, A.G. Rossi, I.L. Megson, Russell Edward Morris

School/Research organisations

Abstract

Transition metal-exchanged zeolite-A adsorbs and stores nitric oxide in relatively high capacity (up to 1 mmol of NO/g of zeolite). The stored NO is released on contact with an aqueous environment under biologically relevant conditions of temperature and pH. The release of the NO can be tuned by altering the chemical composition of the zeolite, by controlling the amount of water contacting the zeolite, and by blending the zeolite with different polymers. The high capacity of zeolite for NO makes it extremely attractive for use in biological and medical applications, and our experiments indicate that the NO released from Co-exchanged zeolite-A inhibits platelet aggregation and adhesion of human platelets in vitro.

Close

Details

Original languageEnglish
Pages (from-to)502-509
Number of pages8
JournalJournal of the American Chemical Society
Volume128
Issue number2
DOIs
Publication statusPublished - 18 Jan 2006

    Research areas

  • NITRIC-OXIDE RELEASE, POLYMERIC FILMS, NITROGEN MONOXIDE, ADSORPTION, ENDOTHELIUM, COMPLEXES, STENTS, THROMBORESISTANT, DESORPTION, CATALYSTS

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Multifaceted study of the interactions between CPO-27-Ni and polyurethane and their impact on nitric oxide release performance

    Vornholt, S. M., Duncan, M. J., Warrender, S. J., Semino, R., Ramsahye, N. A., Maurin, G., Smith, M. W., Tan, J-C., Miller, D. N. & Morris, R. E., 30 Dec 2020, In: ACS Applied Materials & Interfaces. 12, 52, p. 58263-58276

    Research output: Contribution to journalArticlepeer-review

  2. Antibacterial efficacy from NO-releasing MOF–polymer films

    Duncan, M. J., Wheatley, P. S., Coghill, E. M., Vornholt, S. M., Warrender, S. J., Megson, I. L. & Morris, R. E., 7 Oct 2020, In: Materials Advances. 1, 7, p. 2509-2519 11 p.

    Research output: Contribution to journalArticlepeer-review

  3. Advances in organic anode materials for Na-/K-Ion rechargeable batteries

    Desai, A. V., Morris, R. E. & Armstrong, R., 18 Sep 2020, In: CHEMSUSCHEM. 13, 18, p. 4866-4884 20 p.

    Research output: Contribution to journalReview articlepeer-review

  4. Preventing undesirable structure flexibility in pyromellitate metal organic frameworks

    Hayes, O. G., Warrender, S. J., Cordes, D. B., Duncan, M. J., Slawin, A. M. Z. & Morris, R. E., 15 Jul 2020, In: European Journal of Inorganic Chemistry. 2020, 26, p. 2537-2544 8 p.

    Research output: Contribution to journalArticlepeer-review

  5. Following the unusual breathing behaviour of 17O-enriched mixed-metal (Al,Ga)-MIL-53 using NMR crystallography

    Rice, C. M., Davis, Z. H., McKay, D., Bignami, G. P. M., Chitac, R. G., Dawson, D. M., Morris, R. E. & Ashbrook, S. E., 14 Jul 2020, In: Physical Chemistry Chemical Physics. 22, 26, p. 14514-14526 13 p.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. Journal of the American Chemical Society (Journal)

    David Trevor Richens (Editor)

    2005 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

Related by journal

  1. A deep blue B,N-doped heptacene emitter that shows both thermally activated delayed fluorescence and delayed fluorescence by triplet-triplet annihilation

    Madayanad Suresh, S., Duda, E., Hall, D., Yao, Z., Bagnich, S., Slawin, A. M. Z., Bässler, H., Beljonne, D., Buck, M., Olivier, Y., Köhler, A. & Zysman-Colman, E., 8 Apr 2020, In: Journal of the American Chemical Society. 142, 14, p. 6588–6599

    Research output: Contribution to journalArticlepeer-review

  2. Difluorocarbene generation from TMSCF3: kinetics and mechanism of NaI-mediated and Si-induced anionic chain reactions

    García-Domínguez, A., West, T. H., Primozic, J. J., Grant, K. M., Johnston, C. P., Cumming, G. G., Leach, A. G. & Lloyd-Jones, G. C., 26 Aug 2020, In: Journal of the American Chemical Society. 142, 34, p. 14649-14663

    Research output: Contribution to journalArticlepeer-review

  3. Encoding multiple reactivity modes within a single synthetic replicator

    Robertson, C. C., Kosikova, T. & Philp, D., 15 May 2020, In: Journal of the American Chemical Society. Just Accepted

    Research output: Contribution to journalArticlepeer-review

  4. Facile, room-temperature 17O enrichment of zeolite frameworks revealed by solid-state NMR spectroscopy

    Pugh, S. M., Wright, P. A., Law, D., Thompson, N. & Ashbrook, S. E., 15 Jan 2020, In: Journal of the American Chemical Society. 142, 2, p. 900-906 7 p.

    Research output: Contribution to journalArticlepeer-review

  5. Hydrogenative depolymerization of nylons

    Kumar, A., von Wolff, N., Rauch, M., Zou, Y-Q., Shmul, G., Ben-David, Y., Leitus, G., Avram, L. & Milstein, D., 19 Aug 2020, In: Journal of the American Chemical Society. 142, 33, p. 14267-14275

    Research output: Contribution to journalArticlepeer-review

ID: 372324

Top