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One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase

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Author(s)

Michael J. Corr, Duncan R. M. Smith, Rebecca J. M. Goss

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Abstract

We report, for the first time, the use of tryptophan synthase in the generation of L- dihalotryptophans and L-alkynyltryptophans. These previously unpublished compounds will be useful tools in the generation of probes for chemical biology, in biosynthetic diversification and as convenient building blocks for synthesis.
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Original languageEnglish
Pages (from-to)7306-7310
Number of pages5
JournalTetrahedron
Volume72
Issue number46
Early online date9 Feb 2016
DOIs
StatePublished - 17 Nov 2016

    Research areas

  • Biotransformation, Dihalotryptophan, Alkynyltryptophan, Tryptophan synthase

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