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Optimal cross-over designs for full interaction models

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Abstract

We consider repeated measurement designs when a residual or carry-over effect may be present in at most one later period. Since assuming an additive model may be unrealistic for some applications and leads to biased estimation of treatment effects, we consider a model with interactions between carry-over and direct treatment effects. When the aim of the experiment is to study the effects of a treatment used alone, we obtain universally optimal approximate
designs. We also propose some efficient designs with a reduced number of subjects.
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Original languageEnglish
Pages (from-to)2282-2300
Number of pages19
JournalAnnals of Statistics
Volume42
Issue number6
Early online date4 Nov 2014
DOIs
Publication statusPublished - Nov 2014

    Research areas

  • Cross-over designs, Repeated measurement designs, Interference models, Optimal design, Total effects

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