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Orcokinin peptides in developing and adult crustacean stomatogastric nervous systems and pericardial organs

Research output: Contribution to journalArticlepeer-review

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Author(s)

Lingjun Li, Stefan R Pulver, Wayne P Kelley, Vatsala Thirumalai, Jonathan V Sweedler, Eve Marder

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Abstract

The orcokinins are a family of neuropeptides recently isolated from several crustacean species. We found orcokinin-like immunoreactivity in the stomatogastric nervous systems and pericardial organs of three decapod crustacean species, Homarus americanus, Cancer borealis, and Panulirus interruptus. The neuropil of the stomatogastric ganglion was stained in adults of all three species as well as in embryonic and larval H. americanus. In H. americanus, the somata giving rise to this projection were found in the inferior ventricular nerve. Matrix-assisted laser desorption/ionization mass spectrometry mass profiling and sequencing with postsource decay led to the identification of six different orcokinin family peptides, including those previously described in other decapods and two novel shorter peptides. Application of exogenous [Ala(13)]orcokinin to the stomatogastric ganglion of H. americanus resulted in changes in the pyloric rhythm. Specifically, the number of lateral pyloric (LP) neuron spikes/burst decreased, and the phase of firing of the pyloric neurons was altered. Together, these data indicate that the orcokinins are likely to function as modulators of the crustacean stomatogastric ganglion.
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Details

Original languageEnglish
Pages (from-to)227-44
Number of pages18
JournalThe Journal of Comparative Neurology
Volume444
Issue number3
DOIs
Publication statusPublished - 12 Mar 2002

    Research areas

  • Aging, Amino Acid Sequence, Animals, Brachyura, Electrophysiology, Embryo, Nonmammalian, Immunohistochemistry, Larva, Molecular Sequence Data, Nephropidae, Nervous System, Nervous System Physiological Phenomena, Neuropeptides, Peptide Fragments, Pericardium, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Stomach, Tissue Distribution

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