Skip to content

Research at St Andrews

Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestation during the first trimester

Research output: Contribution to journalArticlepeer-review

Author(s)

Ali Abbara, Maya Al-Memar, Maria Phylactou, Christopher Kyriacou, Pei Chia Eng, Rans Nadir, Chioma Izzi-Engbeaya, Sophie A. Clarke, Edouard G. Mills, Elisabeth Daniels, Lechun Huo, Ewa Pacuszka, Lisa Yang, Bijal Patel, Tricia Tan, Paul Bech, Alexander N. Comninos, Hanine Fourie, Tom Kelsey, Tom Bourne & 1 more Waljit S. Dhillo

School/Research organisations

Abstract

Objective: To compare the performance of kisspeptin and beta human chorionic gonadotropin (βhCG), both alone and in combination, as biomarkers for miscarriage throughout the first trimester.

Design: Prospective, nested case-control study.

Setting: Tertiary Centre, Queen Charlotte Hospital, London, United Kingdom.

Patient(s): Adult women who had miscarriages (n = 95, 173 samples) and women with healthy pregnancies (n = 265, 557 samples).Intervention(s)The participants underwent serial ultrasound scans and blood sampling for measurement of plasma kisspeptin and βhCG levels during the first trimester.

Main Outcome Measure(s): The ability of plasma kisspeptin and βhCG levels to distinguish pregnancies complicated by miscarriage from healthy pregnancies unaffected by miscarriage.

Result(s): Gestation-adjusted levels of circulating kisspeptin and βhCG were lower in samples from women with miscarriages than in women with healthy pregnancies by 79% and 70%, respectively. The area under the receiver-operating characteristic curve for identifying miscarriage during the first trimester was 0.874 (95% confidence interval [CI] 0.844–0.904) for kisspeptin, 0.859 (95% CI 0.820–0.899) for βhCG, and 0.916 (95% CI 0.886–0.946) for the sum of the two markers. The performance of kisspeptin in identifying miscarriage improved with increasing length of gestation, whereas that of βhCG worsened. A decision matrix incorporating kisspeptin, βhCG, and gestational age had 83% to 87% accuracy for the prediction of miscarriage.

Conclusion(s): Plasma kisspeptin is a promising biomarker for miscarriage and provides additional value to βhCG alone, especially during later gestational weeks of the first trimester.
Close

Details

Original languageEnglish
Pages (from-to)809-819
Number of pages11
JournalFertility and Sterility
Volume116
Issue number3
Early online date27 May 2021
DOIs
Publication statusPublished - Sep 2021

    Research areas

  • Kisspeptin, Miscarriage, Pregnancy

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Changes in circulating kisspeptin levels during each trimester in women with antenatal complications

    Abbara, A., Al-Memar, M., Phylactou, M., Daniels, E., Patel, B., Chia Eng, P., Nadir, R., Izzi-Engbeaya, C., Clarke, S., Millis, E., Hunjan, T., Pacuszka, E., Yang, L., Bech, P., Tan, T., Comninos, A., Kelsey, T., Kyriacou, C., Fourie, H., Bourne, T. & 1 others, Dhillo, W., 25 Aug 2021, (E-pub ahead of print) In: Journal of Clinical Endocrinology & Metabolism. Advance Article

    Research output: Contribution to journalArticlepeer-review

  2. Clinical and biochemical discriminants between Functional Hypothalamic Amenorrhoea (FHA) and Polycystic Ovary Syndrome (PCOS)

    Phylactou, M., Clarke, S. A., Patel, B., Baggaley, C., Jayasena, C. N., Kelsey, T., Comninos, A. N., Dhillo, W. S. & Abbara, A., Aug 2021, In: Clinical Endocrinology. 95, 2, p. 239-252

    Research output: Contribution to journalReview articlepeer-review

  3. Comparing affordable blood tests and PET CT scans to improve two year survival rates in children, adolescents and young adults with Hodgkin lymphoma in South Africa

    Geel, J., Kelsey, T., Hramyka, A., Myezo, K., Hendricks, M., Ngcana, T., Omar, F., Goga, Y., Neethling, B., Netshituni, V., van Zyl, A., Madzhia, E., Mathew, R., Ballot, D. & Metzger, M., 14 Jul 2021, (Accepted/In press).

    Research output: Contribution to conferenceAbstractpeer-review

  4. Long-term follow up to assess criteria for ovarian tissue cryopreservation for fertility preservation in young women and girls with cancer

    Howie, R., Duffin, K., Kelsey, T., Wallace, W. H. B. & Anderson, R. A., Jul 2021, In: Human Reproduction. 36, p. 98-98 1 p.

    Research output: Contribution to journalAbstractpeer-review

  5. Use of a high-sensitivity anti-Mullerian hormone (AMH) assay to determine ovarian function after chemotherapy for early breast cancer

    Clatot, F., Kelsey, T., Lambertini, M., Olympos, N., Duhamel, O., Perdix, A. & Anderson, R., 30 May 2021, In: Journal of Clinical Oncology. 39, 15_suppl

    Research output: Contribution to journalAbstractpeer-review

Related by journal

  1. Shortcomings of an unphysiological triggering of oocyte maturation using human chorionic gonadotropin

    Andersen, C. Y., Kelsey, T., Mamsen, L. & Vuong, L. N., 1 Aug 2020, In: Fertility and Sterility. 114, 2, p. 200-208

    Research output: Contribution to journalArticlepeer-review

  2. Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation

    Mamsen, L. S., Charkiewicz, K., Anderson, R. A., Telfer, E. E., McLaughlin, M., Kelsey, T. W., Kristensen, S. G., Gook, D. A., Ernst, E. & Andersen, C. Y., Jun 2019, In: Fertility and Sterility. 111, 6, p. 1217-1225.e3 12 p.

    Research output: Contribution to journalArticlepeer-review

  3. Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years

    El Issaoui, M., Giorgine, V., Mamsen, L. S., Rechnitzer, C., Birkebæk, N., Clausen, N., Kelsey, T. W. & Andersen, C. Y., Dec 2016, In: Fertility and Sterility. 106, 7, p. 1757–1762.e1

    Research output: Contribution to journalArticlepeer-review

  4. Fertility preservation in pre-pubertal girls with cancer: the role of ovarian tissue cryopreservation

    Wallace, W. H. B., Kelsey, T. W. & Anderson, R. A., Jan 2016, In: Fertility and Sterility. 105, 1, p. 6-12 7 p.

    Research output: Contribution to journalArticlepeer-review

ID: 273700366

Top