Skip to content

Research at St Andrews

Perirhinal cortex and the recognition of relative familiarity

Research output: Contribution to journalArticlepeer-review

Open Access permissions

Open

Author(s)

Kamar E. Ameen-Ali, Magali Sivakumaran, Madeline J. Eacott, Akira Robert O'Connor, James Alexander Ainge, Alexander Easton

School/Research organisations

Abstract

Spontaneous object recognition (SOR) is a widely used task of recognition memory in rodents which relies on their propensity to explore novel (or relatively novel) objects. Network models typically define perirhinal cortex as a region required for recognition of previously seen objects largely based on findings that lesions or inactivations of this area produce SOR deficits. However, relatively little is understood about the relationship between the activity of cells in the perirhinal cortex that signal novelty and familiarity and the behavioural responses of animals in the SOR task. Previous studies have used objects that are either highly familiar or absolutely novel, but everyday memory is for objects that sit on a spectrum of familiarity which includes objects that have been seen only a few times, or objects that are similar to objects which have been previously experienced. We present two studies that explore cellular activity (through c-fos imaging) within perirhinal cortex of rats performing SOR where the familiarity of objects has been manipulated. Despite robust recognition memory performance, we show no significant changes in perirhinal activity related to the level of familiarity of the objects. Reasons for this lack of familiarity-related modulation in perirhinal cortex activity are discussed. The current findings support emerging evidence that perirhinal responses to novelty are complex and that task demands are critical to the involvement of perirhinal cortex in the control of object recognition memory.
Close

Details

Original languageEnglish
Article number107439
JournalNeurobiology of Learning and Memory
VolumeIn press
Early online date14 Apr 2021
DOIs
Publication statusE-pub ahead of print - 14 Apr 2021

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Distance- rather than location-based temporal judgements are more accurate during episodic recall in a real-world task

    Kuruvilla, M. V., O'Connor, A. R. & Ainge, J. A., 25 Jun 2020, In: Memory. Latest Articles

    Research output: Contribution to journalArticlepeer-review

  2. The discrimination ratio derived from novel object recognition tasks as a measure of recognition memory sensitivity, not bias

    Sivakumaran, M. H., MacKenzie, A. K., Callan, I. R., Ainge, J. A. & O'Connor, A. R., 1 Aug 2018, In: Scientific Reports. 8, 11579.

    Research output: Contribution to journalArticlepeer-review

  3. Disambiguating past events: accurate source memory for time and context depends on different retrieval processes

    Persson, B. M., Ainge, J. A. & O'Connor, A. R., Jul 2016, In: Neurobiology of Learning and Memory. 132, p. 40-48 9 p.

    Research output: Contribution to journalArticlepeer-review

  4. Object and object-memory representations across the proximodistal axis of CA1

    Vandrey, B., Duncan, S. & Ainge, J. A., 4 May 2021, In: Hippocampus. Early View, 16 p.

    Research output: Contribution to journalArticlepeer-review

  5. Lateral entorhinal cortex lesions impair both egocentric and allocentric object-place associations

    Kuruvilla, M. V., Wilson, D. I. G. & Ainge, J. A., 14 Jul 2020, In: Brain and Neuroscience Advances. 4, p. 1-11 11 p.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. Occasion setters determine responses of putative DA neurons to discriminative stimuli

    Aquili, L., Bowman, E. M. & Schmidt, R., Sep 2020, In: Neurobiology of Learning and Memory. 173, 10 p., 107270.

    Research output: Contribution to journalArticlepeer-review

  2. Disambiguating past events: accurate source memory for time and context depends on different retrieval processes

    Persson, B. M., Ainge, J. A. & O'Connor, A. R., Jul 2016, In: Neurobiology of Learning and Memory. 132, p. 40-48 9 p.

    Research output: Contribution to journalArticlepeer-review

  3. Updating of action-outcome associations is prevented by inactivation of the posterior pedunculopontine tegmental nucleus

    MacLaren, D. A. A., Wilson, D. I. G. & Winn, P., May 2013, In: Neurobiology of Learning and Memory. 102, p. 28-33 6 p.

    Research output: Contribution to journalArticlepeer-review

  4. The effect of striatal dopamine depletion and the adenosine A2a antagonist KW-6002 on reversal learning in rats

    O'Neill, M. & Brown, V. J., Jul 2007, In: Neurobiology of Learning and Memory. 88, 1, p. 75-81 7 p.

    Research output: Contribution to journalArticlepeer-review

ID: 273818506

Top