Skip to content

Research at St Andrews

Phospholipase C-η activity may contribute to Alzheimer’s disease-associated calciumopathy.

Research output: Contribution to journalArticle

DOI

Abstract

Alzheimer’s disease (AD) is associated with altered neuronal Ca2+ homeostasis. Ca2+ is known to accumulate in AD-affected neurons leading to deficits in neurological activity that are characteristic of the disease. This has led to the coinage of the term “calciumopathy”. However, the mechanisms of how and why Ca2+ levels are increased in the AD-affected brain remain unknown. Identifying these mechanisms is crucial for our ability to treat and understand the disease processes that are occurring. Recent work has revealed the existence of a novel signaling pathway that may contribute toward this calciumopathy. Phospholipase C-η (PLCη) enzymes have recently been implicated in the modulation and amplification of Ca2+ signals and are known to be expressed in neuronal regions of the brain associated with cognition and memory. In this article their potential impact on neuronal Ca2+ signaling and AD pathogenesis is discussed.
Close

Details

Original languageEnglish
Pages (from-to)737-744
Number of pages8
JournalJournal of Alzheimer's Disease
Volume30
Early online date4 Apr 2012
DOIs
Publication statusPublished - Jun 2012

    Research areas

  • CALCIUM, DEMENTIA, INOSITOL 1,4,5-TRISPHOSPHATE, phospholipase, signalling pathway

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Reduced plasma magnesium levels in type-1 diabetes associate with prothrombotic changes in fibrin clotting and fibrinolysis

    Sobczak, A. I. S., Phoenix, F. A., Pitt, S. J., Ajjan, R. A. & Stewart, A. J., 3 Jan 2020, In : Thrombosis and Haemostasis. eFirst, 10 p.

    Research output: Contribution to journalArticle

  2. Coagulatory defects in type-1 and type-2 diabetes

    Sobczak, A. I. S. & Stewart, A. J., 16 Dec 2019, In : International Journal of Molecular Sciences. 20, 24, 28 p., 6345.

    Research output: Contribution to journalReview article

  3. The X files: ''The mystery of X chromosome instability in Alzheimer's disease''

    Bajic, V. P., Essak, M., Zivkovic, L., Stewart, A. J., Zafirovic, S., Bajic, V., Gojobori, T., Isenovic, E. & Spremo-Potparevic, B., 13 Dec 2019, (Accepted/In press) In : Frontiers in Genetics.

    Research output: Contribution to journalReview article

  4. A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution

    Coverdale, J. P. C., Barnett, J. P., Adamu, A. H., Griffiths, E. J., Stewart, A. J. & Blindauer, C. A., 1 Nov 2019, In : Metallomics. 11, 11, p. 1805-1819 15 p.

    Research output: Contribution to journalArticle

  5. Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation

    Sobczak, A. I. S., Katundu, K. G. H., Phoenix, F. A., Khazaipoul, S., Yu, R., Lampiao, F., Stefanowicz, F., Blindauer, C. A., Pitt, S. J., Smith, T. K., Ajjan, R. A. & Stewart, A. J., 28 Aug 2019, In : biorxiv. 38 p.

    Research output: Contribution to journalArticle

Related by journal

  1. Bioprofile analysis: a new approach for the analysis of biomedical data in Alzheimer's disease

    Escudero, J., Ifeachor, E., Zajicek, J. P. & Alzheimer’s Disease Neuroimaging Initiative, 2012, In : Journal of Alzheimer's Disease. 32, 4, p. 997-1010 14 p.

    Research output: Contribution to journalArticle

Related by journal

  1. Journal of Alzheimer's Disease (Journal)

    Alan J. Stewart (Editor)
    2013

    Activity: Publication peer-review and editorial work typesEditor of research journal

ID: 17731516

Top