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Phosphorescent cationic iridium(III) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging

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Frauke Schibilla, Anna Holthenrich, Boyi Song, Anna Lívia Linard Matos, David Grill, Diego Rota Martir, Volker Gerke, Eli Zysman-Colman, Bart Jan Ravoo

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Abstract

We report cationic Ir(III) complexes functionalized with adamantyl groups designed to bind to β-cyclodextrin vesicles (CDV) with high affinity (Ka = 1·106 M-1). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(III) complexes shows increased and significantly blue-shifted emission due to the lower mobility of the Ir(III)-complexes residing in the less polar environment of the vesicle surface. Ir(III)-decorated CDV are efficiently taken up by cells and can be used in live cell imaging. The CDV act as carriers to transport the phosphorescent complexes into cells where they selectively stain mitochondria.
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Original languageEnglish
Pages (from-to)7822-7828
Number of pages7
JournalChemical Science
Volume9
Issue number40
Early online date9 Aug 2018
DOIs
Publication statusPublished - 28 Oct 2018

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