Skip to content

Research at St Andrews

Plasma fatty acid levels may regulate the Zn2+-dependent activities of histidine-rich glycoprotein.

Research output: Contribution to journalArticlepeer-review

Abstract

Histidine-rich glycoprotein (HRG) is a plasma adaptor protein involved in the formation of protein complexes that regulate a number of biological processes in the blood, most notably coagulation and the immune system. Elevated levels of HRG are clinically linked to thrombotic disorders such as blood vessel occlusion. A large body of evidence suggests that Zn2+ ions stimulates HRG-complex formation; however, under normal conditions the vast majority of Zn2+ in the blood is bound to human serum albumin (HSA). We have previously demonstrated that high levels of fatty acid act as an allosteric switch which disrupts the major Zn2+-binding site on HSA. Transient or sustained elevation of plasma fatty acid levels may therefore increase the proportion of plasma Zn2+ associated with HRG. We speculate that this mechanism may potentiate an increased risk of thrombosis in individuals with elevated fatty acid levels such as those associated with cancer, obesity and diabetes.
Close

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Leptin and obesity

    Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A. J., Gojobori, T. & Isenovic, E. R., 30 Apr 2021, (Accepted/In press) In: Frontiers in Endocrinology.

    Research output: Contribution to journalReview articlepeer-review

  2. Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes

    Sobczak, A. I. S., Katundu, K. G. H., Phoenix, F. A., Khazaipoul, S., Yu, R., Lampiao, F., Stefanowicz, F., Blindauer, C. A., Pitt, S. J., Smith, T. K., Ajjan, R. A. & Stewart, A. J., 21 Mar 2021, In: Chemical Science. 12, 11, p. 4079-4093 15 p.

    Research output: Contribution to journalArticlepeer-review

  3. Ablation of Enpp6 results in transient bone hypomineralization

    Dillon, S., Suchacki, K., Hsu, S-N., Stephen, L. A., Wang, R., Cawthorn, W. P., Stewart, A. J., Nudelman, F., Morton, N. M. & Farquharson, C., Feb 2021, In: JBMR Plus. 5, 2, 11 p., e10439.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. Babesia divergens glycosylphosphatidylinositols modulate blood coagulation and induce Th2-biased cytokine profiles in antigen presenting cells

    Debierre-Grockiego, F., Smith, T. K., Delbecq, S., Ducournau, C., Lantier, L., Schmidt, J., Brès, V., Dimier-Poisson, I., Schwarz, R. T. & Cornillot, E., Dec 2019, In: Biochimie. 167, p. 135-144 10 p.

    Research output: Contribution to journalArticlepeer-review

  2. Crystal structures of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyrl (haba) group

    Kondo, J., Francois, B., Russell, R. J. M., Murray, JB. & Westhof, E., Aug 2006, In: Biochimie. 88, p. 1027-1031 5 p.

    Research output: Contribution to journalArticlepeer-review

  3. Inhibitors of glycosyl-phosphatidylinositol anchor biosynthesis

    de Macedo, C. S., Shams-Eldin, H., Smith, T. K., Schwarz, R. T. & Azzouz, N., 2003, In: Biochimie. 85, 3-4, p. 465-472 8 p.

    Research output: Contribution to journalReview articlepeer-review

  4. The translational stop signal: Codon with a context, or extended factor recognition element?

    Tate, WP., Poole, ES., Dalphin, ME., Major, LL., Crawford, DJG. & Mannering, SA., 1996, In: Biochimie. 78, 11-12, p. 945-952 8 p.

    Research output: Contribution to journalArticlepeer-review

ID: 450927

Top