Skip to content

Research at St Andrews

Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia–reperfusion injury

Research output: Contribution to journalArticle

Author(s)

Sylvain Le Pape, Elena Dimitrova, Patrick Hannaert, Alexander Konovalov, Romain Volmer, David Ron, Raphaël Thuillier, Thierry Hauet

School/Research organisations

Abstract

The unfolded protein response (UPR) – the endoplasmic reticulum stress response – is found in various pathologies including ischemia–reperfusion injury (IRI). However, its role during IRI is still unclear. Here, by combining two different bioinformatical methods – a method based on ordinary differential equations (Time Series Network Inference) and an algebraic method (probabilistic polynomial dynamical systems) – we identified the IRE1α–XBP1 and the ATF6 pathways as the main UPR effectors involved in cell’s adaptation to IRI. We validated these findings experimentally by assessing the impact of their knock-out and knock-down on cell survival during IRI.
Close

Details

Original languageEnglish
Pages (from-to)3062-3067
JournalFEBS Letters
Volume588
Issue number17
Early online date16 Jun 2014
DOIs
StatePublished - 25 Aug 2014

    Research areas

  • Ischemia–reperfusion injury (IRI), Unfolded protein response (UPR), Endothelial cells (EC), Murine embryonic cells (MEC), Probabilistic polynomial dynamical systems (PDS), Gene regulatory networks (GRN)

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. On the Gruenberg–Kegel graph of integral group rings of finite groups

    Konovalov, A. & Kimmerle, W. 24 Aug 2017 In : International Journal of Algebra and Computation. Online Ready, 13 p.

    Research output: Contribution to journalArticle

  2. The status of the Zassenhaus conjecture for small groups

    Bächle, A., Herman, A., Konovalov, A., Margolis, L. & Singh, G. 5 Apr 2017 In : Experimental Mathematics. Latest Articles, 6 p.

    Research output: Contribution to journalArticle

  3. Software Carpentry: Programming with GAP

    Software Carpentry team 18 Nov 2016 Zenodo

    Research output: Other contribution

  4. HPC-GAP: engineering a 21st-century High-Performance Computer algebra system

    Behrends, R., Hammond, K., Janjic, V., Konovalov, A., Linton, S. A., Loidl, H-W., Maier, P. & Trinder, P. 10 Sep 2016 In : Concurrency and Computation : Practice and Experience. 28, 13, p. 3606-3636 33 p.

    Research output: Contribution to journalArticle

  5. Ten Simple Rules for taking advantage of Git and GitHub

    Perez-Riverol, Y., Gatto, L., Wang, R., Sachsenberg, T., Uszkoreit, J., da Veiga Leprevost, F., Fufezan, C., Ternent, T., Eglen, S. J., Katz, D. S., Pollard, T. J., Konovalov, A., Flight, R. M., Blin, K. & Vizcaíno, J. A. 14 Jul 2016 In : PLoS Computational Biology. 12, 7, 11 p., e1004947

    Research output: Contribution to journalArticle

Related by journal

  1. Conformation-specific crosslinking of mitochondrial complex I

    Ciano, M., Fuszard, M. A., Heide, H., Botting, C. H. & Galkin, A. 2 Apr 2013 In : FEBS Letters. 587, 7, p. 867-872 6 p.

    Research output: Contribution to journalArticle

  2. Purification and functional inactivation of the fission yeast MCMMCM-BP complex

    Li, J., Schnick, J., Hayles, J. & MacNeill, S. A. 15 Dec 2011 In : FEBS Letters. 585, 24, p. 3850-3855 6 p.

    Research output: Contribution to journalArticle

  3. ERp57 interacts with conserved cysteine residues in the MHC class I peptides-binding groove.

    Antoniou, A. N., Santos, S., Campbell, E. C., Lynch, S., Arosa, F. A. & Powis, S. J. 15 May 2007 In : FEBS Letters. 581, p. 1988-1892 5 p.

    Research output: Contribution to journalArticle

ID: 157231731