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Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia–reperfusion injury

Research output: Contribution to journalArticle

Author(s)

Sylvain Le Pape, Elena Dimitrova, Patrick Hannaert, Alexander Konovalov, Romain Volmer, David Ron, Raphaël Thuillier, Thierry Hauet

School/Research organisations

Abstract

The unfolded protein response (UPR) – the endoplasmic reticulum stress response – is found in various pathologies including ischemia–reperfusion injury (IRI). However, its role during IRI is still unclear. Here, by combining two different bioinformatical methods – a method based on ordinary differential equations (Time Series Network Inference) and an algebraic method (probabilistic polynomial dynamical systems) – we identified the IRE1α–XBP1 and the ATF6 pathways as the main UPR effectors involved in cell’s adaptation to IRI. We validated these findings experimentally by assessing the impact of their knock-out and knock-down on cell survival during IRI.
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Details

Original languageEnglish
Pages (from-to)3062-3067
JournalFEBS Letters
Volume588
Issue number17
Early online date16 Jun 2014
DOIs
Publication statusPublished - 25 Aug 2014

    Research areas

  • Ischemia–reperfusion injury (IRI), Unfolded protein response (UPR), Endothelial cells (EC), Murine embryonic cells (MEC), Probabilistic polynomial dynamical systems (PDS), Gene regulatory networks (GRN)

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