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Postprandial expression of growth-related genes in Atlantic salmon (Salmo salar L.) juveniles fasted for 1 week and fed a single meal to satiation

Research output: Contribution to journalArticle

Abstract

We investigated postprandial changes in transcript abundance following a single satiating meal in juvenile Atlantic salmon (Salmo salar L.) (about 70 g body mass) following fasting for 1 week at 12 degrees C. The expression of twenty-three growth-related genes was determined in fast myotomal muscle using quantitative real-time PCR at the following postprandial time points: -12, 0, 1, 3, 6, 12, 24, 48 and 96 h. The gut was fullest 1-6 h after feeding and emptied within 48-96 h. IGF-I, MyoD1c, MRF4 and myf5 transcripts were sharply up-regulated within 1 h of refeeding and are promising candidate genes involved in a fast-response signalling system that regulates fish myotomal muscle growth. These genes clustered together with MyoD1b and suggest a coordinated regulation to favour resumption of myogenesis as an early response to feeding. Insulin-like growth factor (IGF)-II and the ubiquitin ligase MAFbx/atrogin-1 were initially down-regulated but restored to initial values after 12 h. It is also suggested that local production of IGF-I within the muscle might suppress catabolic pathways depressing MAFbx/atrogin-1.

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Original languageEnglish
Pages (from-to)2148-2157
Number of pages10
JournalBritish Journal of Nutrition
Volume108
Issue number12
DOIs
Publication statusPublished - 28 Dec 2012

    Research areas

  • Salmo salar L., Myogenesis, Refeeding and fasting, Nutrient availability, Insulin-like growth factor system, TROUT ONCORHYNCHUS-MYKISS, MESSENGER-RNA EXPRESSION, GILTHEAD SEA BREAM, RAINBOW-TROUT, COMPENSATORY GROWTH, SKELETAL-MUSCLE, FACTOR-I, IGF-I, SIGNALING PATHWAYS, REGULATORY FACTORS

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