Skip to content

Research at St Andrews

Pretreatment anti-Müllerian hormone predicts for loss of ovarian function after chemotherapy for early breast cancer

Research output: Contribution to journalArticle

Author(s)

Richard Anderson, Mikkel Rosendahl, Tom Kelsey, David Cameron

School/Research organisations

Abstract

Aim: Improving survival for women with early breast cancer (eBC) requires greater attention to the consequences of treatment, including risk to ovarian function. We have assessed whether biochemical markers of the ovarian reserve might improve prediction of chemotherapy related amenorrhoea. Methods: Women (n = 59, mean age 42.6 years [(range 23.3–52.5]) with eBC were recruited before any treatment. Pretreatment ovarian reserve markers (anti-Müllerian hormone [AMH], follicle-stimulating hormone [FSH], inhibin B) were analysed in relation to ovarian status at 2 years. Results: Pretreatment AMH was significantly lower in women with amenorrhoea at 2 years (4.0 ± 0.9 pmol/L versus 17.2 ± 2.5, P < 0.0001), but FSH and inhibin B did not differ between groups. By logistic regression, pretreatment AMH, but not age, FSH or inhibin B, was an independent predictor of ovarian status at 2 years (P = 0.005; odds ratio 0.013). We combined these data with a similar cohort (combined n = 75); receiver–operator characteristic analysis for AMH gave area under curve (AUC) of 0.90 (95% confidence interval (CI) 0.82–0.97)). A cross-validated classification tree analysis resulted in a binary classification schema with sensitivity 98.2% and specificity 80.0% for correct classification of amenorrhoea. Conclusion: Pretreatment AMH is a useful predictor of long term post chemotherapy loss of ovarian function in women with eBC, adding significantly to the only previously established individualising predictor, i.e. age. AMH measurement may assist decision-making regarding treatment options and fertility preservation procedures.
Close

Details

Original languageEnglish
Pages (from-to)3404-3411
JournalEuropean Journal of Cancer
Volume49
Issue number16
Early online date21 Aug 2013
DOIs
Publication statusPublished - Nov 2013

    Research areas

  • AMH, ovarian reserve, Chemotherapy, Amenorrhoea, Fertility, Breast cancer

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Kisspeptin as a novel biomarker for pregnancy complications

    Phylactou, M., Abbara, A., Al-Memar, M., Chia Eng, P., Comninos, AN., Izzi-Engbeaya, C., Clarke, SA., Mills, E., Nadir, R., Sykes, M., Pacuszka, E., Yang, L., Fourie, H., Bech, P., Kelsey, T., Bourne, T. & Dhillo, WS., 5 Nov 2019, Endocrine Abstracts. BioScientifica Ltd., 1 p. OP5.4. (Endocrine Abstracts; vol. 65).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  2. Representation learning for minority and subtle activities in a smart home environment

    Rosales Sanabria, A., Kelsey, T., Dobson, S. A. & Ye, J., 28 Oct 2019, In : Journal of Ambient Intelligence and Smart Environments. Pre-press, p. 1-19

    Research output: Contribution to journalArticle

  3. Anti-Müllerian hormone (AMH) in the diagnosis of menstrual disturbance due to polycystic ovarian syndrome

    Abbara, A., Eng, P. C., Phylactou, M., Clarke, S. A., Hunjan, T., Roberts, R., Vimalesvaran, S., Christopoulous, G., Islam, R., Purugganan, K., Comninos, A. M., Trew, G. H., Salim, R., Hramyka, A., Owens, L., Kelsey, T. W. & Dhillo, W., 26 Sep 2019, In : Frontiers in Endocrinology. 10, 11 p., 656.

    Research output: Contribution to journalArticle

  4. FSH requirements for follicle growth during controlled ovarian stimulation

    Abbara, A., Patel, A. H., Hunjan, T., Clarke, S., Chia, G., Eng, P. C., Phylactou, M., Comninos, A., Lavery, S., Trew, G., Salim, R., Rai, R., Kelsey, T. W. & Dhillo, W., 27 Aug 2019, In : Frontiers in Endocrinology. 10, 11 p., 579.

    Research output: Contribution to journalArticle

  5. Representation learning for minority and subtle activities in a smart home environment

    Rosales Sanabria, A., Kelsey, T. W. & Ye, J., 22 Jul 2019, Proceedings of the IEEE International Conference on Pervasive Computing and Communications (PerCom 2019). IEEE Computer Society, 7 p. 8767417

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

Related by journal

  1. Perinatal complications in female survivors of cancer: a systematic review and meta-analysis

    van der Kooi, A. L., Kelsey, T. W., van den Heuvel-Eibrink, M., Laven, J. S. E., Wallace, W. H. B. & Anderson, R. A., Apr 2019, In : European Journal of Cancer. 111, p. 126-137

    Research output: Contribution to journalArticle

  2. Do participants in adjuvant breast cancer trials reflect the breast cancer patient population?

    Treweek, S., Dryden, R., McCowan, C., Harrow, A. & Thompson, A., May 2015, In : European Journal of Cancer. 51, 8, p. 907-914

    Research output: Contribution to journalArticle

  3. Regulation of exosome release from mammary epithelial and breast cancer cells - a new regulatory pathway

    Riches, A., Campbell, E., Borger, E. & Powis, S., Mar 2014, In : European Journal of Cancer. 50, 5, p. 1025-34 10 p.

    Research output: Contribution to journalArticle

ID: 74633314

Top