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Quantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbeds

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Quantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbeds. / Barnard, Isla Rose Mary; Tierney, Patrick ; Campbell, Catherine Louise; McMillan, Lewis; Moseley, Harry; Eadie, Ewan; Brown, Christian Thomas Alcuin; Wood, Kenneth.

In: Photochemistry and Photobiology, Vol. 94, No. 5, 09.2018, p. 1017-1025.

Research output: Contribution to journalArticlepeer-review

Harvard

Barnard, IRM, Tierney, P, Campbell, CL, McMillan, L, Moseley, H, Eadie, E, Brown, CTA & Wood, K 2018, 'Quantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbeds', Photochemistry and Photobiology, vol. 94, no. 5, pp. 1017-1025. https://doi.org/10.1111/php.12935

APA

Barnard, I. R. M., Tierney, P., Campbell, C. L., McMillan, L., Moseley, H., Eadie, E., Brown, C. T. A., & Wood, K. (2018). Quantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbeds. Photochemistry and Photobiology, 94(5), 1017-1025. https://doi.org/10.1111/php.12935

Vancouver

Barnard IRM, Tierney P, Campbell CL, McMillan L, Moseley H, Eadie E et al. Quantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbeds. Photochemistry and Photobiology. 2018 Sep;94(5):1017-1025. https://doi.org/10.1111/php.12935

Author

Barnard, Isla Rose Mary ; Tierney, Patrick ; Campbell, Catherine Louise ; McMillan, Lewis ; Moseley, Harry ; Eadie, Ewan ; Brown, Christian Thomas Alcuin ; Wood, Kenneth. / Quantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbeds. In: Photochemistry and Photobiology. 2018 ; Vol. 94, No. 5. pp. 1017-1025.

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@article{f06ed161421c45ab8c926ea3f9c04708,
title = "Quantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbeds",
abstract = "Nonmelanoma and melanoma skin cancers are attributable to DNA damage caused by ultraviolet (UV) radiation exposure. One DNA photoproduct, the Cyclobutane Pyrimidine Dimer (CPD), is believed to lead to DNA mutations caused by UV radiation. Using radiative transfer simulations, we compare the number of CPDs directly induced by UV irradiation from artificial and natural UV sources (a standard sunbed and the midday summer Mediterranean sun) for skin types I and II on the Fitzpatrick scale. We use Monte Carlo Radiative Transfer (MCRT) modelling to track the progression of UV photons through a multilayered three dimensional (3D) grid that simulates the upper layers of the skin. By recording the energy deposited in the DNA-containing cells of the basal layer, the number of CPDs formed can be quantified. The aim of this work was to compare the number of CPDs formed in the basal layer of the skin, and by implication the risk of developing cancer, as a consequence of irradiation by artificial and natural sources. Our simulations show that the number of CPDs formed per second during sunbed irradiation is almost three times that formed during solar irradiation. ",
keywords = "UV, UVA, DNA Damage",
author = "Barnard, {Isla Rose Mary} and Patrick Tierney and Campbell, {Catherine Louise} and Lewis McMillan and Harry Moseley and Ewan Eadie and Brown, {Christian Thomas Alcuin} and Kenneth Wood",
note = "Funding: UK EPRSC PhD studentship number EP/N509759/1.",
year = "2018",
month = sep,
doi = "10.1111/php.12935",
language = "English",
volume = "94",
pages = "1017--1025",
journal = "Photochemistry and Photobiology",
issn = "0031-8655",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Quantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbeds

AU - Barnard, Isla Rose Mary

AU - Tierney, Patrick

AU - Campbell, Catherine Louise

AU - McMillan, Lewis

AU - Moseley, Harry

AU - Eadie, Ewan

AU - Brown, Christian Thomas Alcuin

AU - Wood, Kenneth

N1 - Funding: UK EPRSC PhD studentship number EP/N509759/1.

PY - 2018/9

Y1 - 2018/9

N2 - Nonmelanoma and melanoma skin cancers are attributable to DNA damage caused by ultraviolet (UV) radiation exposure. One DNA photoproduct, the Cyclobutane Pyrimidine Dimer (CPD), is believed to lead to DNA mutations caused by UV radiation. Using radiative transfer simulations, we compare the number of CPDs directly induced by UV irradiation from artificial and natural UV sources (a standard sunbed and the midday summer Mediterranean sun) for skin types I and II on the Fitzpatrick scale. We use Monte Carlo Radiative Transfer (MCRT) modelling to track the progression of UV photons through a multilayered three dimensional (3D) grid that simulates the upper layers of the skin. By recording the energy deposited in the DNA-containing cells of the basal layer, the number of CPDs formed can be quantified. The aim of this work was to compare the number of CPDs formed in the basal layer of the skin, and by implication the risk of developing cancer, as a consequence of irradiation by artificial and natural sources. Our simulations show that the number of CPDs formed per second during sunbed irradiation is almost three times that formed during solar irradiation.

AB - Nonmelanoma and melanoma skin cancers are attributable to DNA damage caused by ultraviolet (UV) radiation exposure. One DNA photoproduct, the Cyclobutane Pyrimidine Dimer (CPD), is believed to lead to DNA mutations caused by UV radiation. Using radiative transfer simulations, we compare the number of CPDs directly induced by UV irradiation from artificial and natural UV sources (a standard sunbed and the midday summer Mediterranean sun) for skin types I and II on the Fitzpatrick scale. We use Monte Carlo Radiative Transfer (MCRT) modelling to track the progression of UV photons through a multilayered three dimensional (3D) grid that simulates the upper layers of the skin. By recording the energy deposited in the DNA-containing cells of the basal layer, the number of CPDs formed can be quantified. The aim of this work was to compare the number of CPDs formed in the basal layer of the skin, and by implication the risk of developing cancer, as a consequence of irradiation by artificial and natural sources. Our simulations show that the number of CPDs formed per second during sunbed irradiation is almost three times that formed during solar irradiation.

KW - UV

KW - UVA

KW - DNA Damage

U2 - 10.1111/php.12935

DO - 10.1111/php.12935

M3 - Article

VL - 94

SP - 1017

EP - 1025

JO - Photochemistry and Photobiology

JF - Photochemistry and Photobiology

SN - 0031-8655

IS - 5

ER -

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