Skip to content

Research at St Andrews

Recent advances in understanding the roles of whole genome duplications in evolution

Research output: Contribution to journalReview article

Abstract

Ancient whole-genome duplications (WGDs)—paleopolyploidy events—are key to solving Darwin’s ‘abominable mystery’ of how flowering plants evolved and radiated into a rich variety of species. The vertebrates also emerged from their invertebrate ancestors via two WGDs, and genomes of diverse gymnosperm trees, unicellular eukaryotes, invertebrates, fishes, amphibians and even a rodent carry evidence of lineage-specific WGDs. Modern polyploidy is common in eukaryotes, and it can be induced, enabling mechanisms and short-term cost-benefit assessments of polyploidy to be studied experimentally. However, the ancient WGDs can be reconstructed only by comparative genomics: these studies are difficult because the DNA duplicates have been through tens or hundreds of millions of years of gene losses, mutations, and chromosomal rearrangements that culminate in resolution of the polyploid genomes back into diploid ones (rediploidisation). Intriguing asymmetries in patterns of post-WGD gene loss and retention between duplicated sets of chromosomes have been discovered recently, and elaborations of signal transduction systems are lasting legacies from several WGDs. The data imply that simpler signalling pathways in the pre-WGD ancestors were converted via WGDs into multi-stranded parallelised networks. Genetic and biochemical studies in plants, yeasts and vertebrates suggest a paradigm in which different combinations of sister paralogues in the post-WGD regulatory networks are co-regulated under different conditions. In principle, such networks can respond to a wide array of environmental, sensory and hormonal stimuli and integrate them to generate phenotypic variety in cell types and behaviours. Patterns are also being discerned in how the post-WGD signalling networks are reconfigured in human cancers and neurological conditions. It is fascinating to unpick how ancient genomic events impact on complexity, variety and disease in modern life.
Close

Details

Original languageEnglish
Article number1623
JournalF1000Research
Volume2017
Issue number6
DOIs
StatePublished - 31 Aug 2017

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Two more Posterior Hox genes and Hox cluster dispersal in echinoderms

    Szabó, R. & Ferrier, D. E. K. 27 Dec 2018 In : BMC Evolutionary Biology. 18, 13 p., 203

    Research output: Contribution to journalArticle

  2. Transcriptional regulation of the Ciona Gsx gene in the neural plate

    Hudson, C., Esposito, R., Palladino, A., Staiano, L., Ferrier, D., Faure, E., Lemaire, P., Yasuo, H. & Spagnuolo, A. 21 Dec 2018 In : Developmental Biology. In press

    Research output: Contribution to journalArticle

  3. Amphioxus functional genomics and the origins of vertebrate gene regulation

    Marletaz, F. , Firbas, P. , Maeso, I. , Tena, J. , Bogdanovic, O. , Perry, M. , Wyatt, C. , de la Calle-Mustienes, E. , Bertrand, S. , Burguera, D. , Acemel, R. , van Heeringen, S. , Naranjo, S. , Herrera-Ubeda, C. , Skvortsova, K. , Jimenez-Gancedo, S. , Aldea, D. , Marquez, Y. , Buono, L. , Kozmikova, I. & 41 others Permanyer, J., Louis, A., Albuixech-Crespo, B., Le Petillon, Y., Leon Florian, A., Subirana, L., Balwierz, P. J., Duckett, P., Farahani, E., Aury, J. M., Mangenot, S., Wincker, P., Albalat, R., Benito-Gutierrez, E., Canestro, C., Castro, F., D'Aniello, S., Ferrier, D. E. K., Huang, S., Laudet, V., Marais, G., Pontarotti, P., Schubert, M., Seitz, H., Somorjai, I. M. L., Takahashi, T., Mirabeau, O., Xu, A., Yu, J-K., Carninci, P., Martinez-Morales, J., Crollius, H., Kozmik, Z., Weirauch, M., Garcia-Fernandez, J., Lister, R., Lenhard, B., Holland, P., Escriva, H., Gomez-Skarmeta, J. L. & Irimia, M. 21 Nov 2018 In : Nature. 564, 7734, p. 64-70 29 p.

    Research output: Contribution to journalArticle

  4. Horizons in evolutionary genomics: an interview with David Ferrier

    Ferrier, D. E. K. 1 Nov 2018 In : BMC Biology. 16, 3 p., 124

    Research output: Contribution to journalArticle

  5. Genome biology: unconventional DNA repair in an extreme genome

    Ferrier, D. E. K. & Sogabe, S. 22 Oct 2018 In : Current Biology. 28, 20, p. R1208-R1210

    Research output: Contribution to journalReview article

Related by journal

  1. Metabolic reprogramming during the Trypanosoma brucei life cycle

    Smith, T. K., Bringaud, F., Nolan, D. P. & Figueiredo, L. M. 18 May 2017 In : F1000Research. 6, 683

    Research output: Contribution to journalReview article

  2. Professional medical writing support and the reporting quality of randomized controlled trial abstracts among high-impact general medical journals

    Mills, I., Sheard, C., Hays, M., Douglas, K., Winchester, C. C. & Gattrell, W. T. 23 Sep 2017 In : F1000Research. 6, 12 p., 1489

    Research output: Contribution to journalArticle

  3. Decomposition of mutational context signatures using quadratic programming methods

    Lynch, A. G. 7 Jun 2016 In : F1000Research. 5, 1253

    Research output: Contribution to journalArticle

  4. Whole-genome sequencing of nine esophageal adenocarcinoma cell lines

    Contino, G., Eldridge, M. D., Secrier, M., Bower, L., Elliott, R. F., Weaver, J., Lynch, A. G., Edwards, P. A. W. & Fitzgerald, R. C. 10 Jun 2016 In : F1000Research. 5, 1336

    Research output: Contribution to journalArticle

ID: 250980312