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Recent developments in organoboron chemistry - old dogs, new tricks

Research output: Contribution to journalReview article

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James W. B. Fyfe, Allan J. B. Watson

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Abstract

Organoboron reagents have been synonymous with organic chemistry for over half a century and continue to see widespread application today; for example, classic reactions such as hydroboration and Suzuki-Miyaura cross-coupling are regularly practiced throughout the chemical community. In particular, applications of organoboron compounds have underpinned pharmaceutical and agrochemical development on both discovery and process scales for decades. Although it is noteworthy that these seminal reactions have stood the test of time, continually increasing pressure to improve efficiency in chemical synthesis demands innovation. Over the past few years, through an explosion in the number of new methods for the installation and manipulation of organoboron functional groups, as well as the understanding of their mechanistic operation, organoboron chemistry has risen to this challenge.
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Original languageEnglish
Pages (from-to)31-55
Number of pages5
JournalChemical Reviews
Volume3
Issue number1
Early online date13 Jul 2017
DOIs
Publication statusPublished - 13 Jul 2017

    Research areas

  • Boron, Catalysis, Synthesis, Selectivity, Reactivity

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