Skip to content

Research at St Andrews

Recurrent tuberculosis and associated factors: a five-year countrywide study in Uzbekistan

Research output: Contribution to journalArticle

Author(s)

Jamshid Gadoev, Damin Asadov, Anthony D. Harries, Nargiza Parpieva, Katie Tayler-Smith, Petros Isaakidis, Engy Ali, Sven Gudmund Hinderaker, Gozalov Ogtay, Andrew Ramsay, Avazbek Jalolov, Masoud Dara

School/Research organisations

Abstract

Background:  In Uzbekistan, despite stable and relatively high tuberculosis treatment success rates, relatively high rates of recurrent tuberculosis have recently been reported. Recurrent tuberculosis is when a patient who was treated for pulmonary tuberculosis and cured, later develops the disease again. This requires closer analysis to identify possible causes and recommend interventions to improve the situation. Using countrywide data, this study aimed to analyse trends in recurrent tuberculosis cases and describe their associations with socio-demographic and clinical factors.
Method:  Countrywide retrospective cohort study comparing recurrent tuberculosis patients with all new tuberculosis patients registered within the NTP between January 2006 and December 2010 using routinely collected data. Determinants studied were baseline characteristics and treatment outcomes. Results:  Of 107,380 registered patients during the period January 2006 and December 2010, 9358 (8.7%) were recurrent cases. Between 2006 and 2008, the number of recurrent cases per annum increased from 1530 to 2081, then fell slightly thereafter from 2081 to 1888 cases. The proportion of all notified cases during this period increased from 6.5% to 9.9%. Factors associated with recurrent tuberculosis included age (35–55 years old), having smear positive pulmonary tuberculosis, residing in certain areas of Uzbekistan, having particular co-morbidities (including chronic obstructive pulmonary disease and HIV), and being unemployed, a pensioner or disabled. Recurrent tuberculosis patients also had a higher likelihood of having an unfavourable treatment outcome.
Conclusion:  Despite signs of declining national tuberculosis notifications between 2006 and 2010, the relative proportion of recurrent cases appears to have increased. These findings, together with the identification of possible risk factors associated with recurrent tuberculosis, highlight various areas where Uzbekistan needs to focus its tuberculosis control efforts, particularly in light of the country’s rapidly emerging multi drug resistant tuberculosis epidemic.
Close

Details

Original languageEnglish
Article numbere0176473
Number of pages12
JournalPLoS One
Volume12
Issue number5
DOIs
Publication statusPublished - 4 May 2017

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. The role of active case finding in reducing patient incurred catastrophic costs for tuberculosis in Nepal

    Gurung, S. C., Dixit, K., Rai, B., Caws, M., Paudel, P. R., Dhital, R., Acharya, S., Budhathoki, G., Malla, D., Levy, J. W., van Rest, J., Lönnroth, K., Viney, K., Ramsay, A., Wingfield, T., Basnyat, B., Thapa, A., Squire, B., Wang, D., Mishra, G. & 3 others, Shah, K., Shrestha, A. & de Siqueira-Filha, N. T., 3 Dec 2019, In : Infectious Diseases of Poverty. 8, 15 p., 99.

    Research output: Contribution to journalArticle

  2. Does the Structured Operational Research and Training Initiative (SORT IT) continue to influence health policy and/or practice?

    Tripathy, J. P., Kumar, A. MV., Guillerm, N., Berger, S. D., Bissell, K., Reid, A., Zachariah, R., Ramsay, A. & Harries, A. D., 2018, In : Global Health Action. 11, 1, 11 p.

    Research output: Contribution to journalArticle

  3. New synthetic lipid antigens for rapid serological diagnosis of tuberculosis

    Jones, A., Pitts, M., Al Dulayymi, J. R., Gibbons, J., Ramsay, A., Goletti, D., Gwenin, C. D. & Baird, M. S., 14 Aug 2017, In : PLoS One. 12, 8, 28 p., e0181414.

    Research output: Contribution to journalArticle

  4. Factors underlying Ebola virus infection among health workers, Kenema, Sierra Leone, 2014-2015

    Senga, M., Pringle, K., Ramsay, A., Brett-Major, D. M., Fowler, R. A., French, I., Vandi, M., Sellu, J., Pratt, C., Saidu, J., Shindo, N., Bausch, D. G. & Sierra Leone Kenema District Task Force and Kenema General Hospital, 15 Aug 2016, In : Clinical Infectious Diseases. 63, 4, p. 454-459 6 p.

    Research output: Contribution to journalArticle

  5. Building global capacity for conducting operational research using the SORT IT model: where and who?

    Zachariah, R., Rust, S., Berger, S. D., Guillerm, N., Bissell, K., Delaunois, P., Reid, A. J., Kumar, A. M. V., Olliaro, P. L., Reeder, J. C., Harries, A. D. & Ramsay, A., 9 Aug 2016, In : PLoS One. 11, 8, 14 p., e0160837.

    Research output: Contribution to journalArticle

Related by journal

  1. PLoS ONE (Journal)

    Joanna Louise Kershaw (Reviewer)
    18 Mar 2019

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

  2. PLoS ONE (Journal)

    Catharine Penelope Cross (Member of editorial board)
    1 Sep 2018 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

  3. PLoS ONE (Journal)

    Will Cresswell (Reviewer)
    23 May 2018

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

  4. PLoS ONE (Journal)

    Barbara Dritschel (Member of editorial board)
    May 2018 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

  5. PLoS ONE (Journal)

    Simon Young (Reviewer)
    7 Jun 201719 Jun 2017

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Related by journal

  1. Drivers of the opioid crisis: An appraisal of financial conflicts of interest in clinical practice guideline panels at the peak of opioid prescribing

    Spithoff, S., Leece, P., Sullivan, F., Persaud, N., Belesiotis, P. & Steiner, L., 24 Jan 2020, In : PLoS ONE. 15, 1, 15 p., e0227045.

    Research output: Contribution to journalArticle

  2. Satellite derived offshore migratory movements of southern right whales (Eubalaena australis) from Australian and New Zealand wintering grounds

    Mackay, A. I., Bailleul, F., Carroll, E. L., Andrews-Goff, V., Baker, C. S., Bannister, J., Boren, L., Carlyon, K., Donnelly, D. M., Double, M., Goldsworthy, S. D., Harcourt, R., Holman, D., Lowther, A., Parra, G. J. & Childerhouse, S. J., 7 May 2020, In : PLoS ONE. 15, 5, e0231577.

    Research output: Contribution to journalArticle

  3. The shield of self-compassion: a buffer against disordered eating risk from physical appearance perfectionism

    Bergunde, L. & Dritschel, B., 13 Jan 2020, In : PLoS ONE. 15, 1, 17 p., e0227564.

    Research output: Contribution to journalArticle

  4. Under his thumb the effect of president Donald Trump’s Twitter messages on the US stock market

    Brans, H. & Scholtens, B., 11 Mar 2020, In : PLoS ONE. 15, 3, 11 p., e0229931.

    Research output: Contribution to journalArticle

ID: 249950794

Top