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Reducing toxic reactive carbonyl species in e-cigarette emissions: testing a harm-reduction strategy based on dicarbonyl trapping

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Reducing toxic reactive carbonyl species in e-cigarette emissions : testing a harm-reduction strategy based on dicarbonyl trapping. / de Falco, Bruna; Petridis, Antonios; Paramasivan, Poornima; Troise, Antonio Dario; Scaloni, Andrea; Deeni, Yusuf; Stephens, W. Edryd; Fiore, Alberto.

In: RSC Advances, Vol. 10, No. 36, 05.06.2020, p. 21535-21544.

Research output: Contribution to journalArticlepeer-review

Harvard

de Falco, B, Petridis, A, Paramasivan, P, Troise, AD, Scaloni, A, Deeni, Y, Stephens, WE & Fiore, A 2020, 'Reducing toxic reactive carbonyl species in e-cigarette emissions: testing a harm-reduction strategy based on dicarbonyl trapping', RSC Advances, vol. 10, no. 36, pp. 21535-21544. https://doi.org/10.1039/D0RA02138E

APA

de Falco, B., Petridis, A., Paramasivan, P., Troise, A. D., Scaloni, A., Deeni, Y., Stephens, W. E., & Fiore, A. (2020). Reducing toxic reactive carbonyl species in e-cigarette emissions: testing a harm-reduction strategy based on dicarbonyl trapping. RSC Advances, 10(36), 21535-21544. https://doi.org/10.1039/D0RA02138E

Vancouver

de Falco B, Petridis A, Paramasivan P, Troise AD, Scaloni A, Deeni Y et al. Reducing toxic reactive carbonyl species in e-cigarette emissions: testing a harm-reduction strategy based on dicarbonyl trapping. RSC Advances. 2020 Jun 5;10(36):21535-21544. https://doi.org/10.1039/D0RA02138E

Author

de Falco, Bruna ; Petridis, Antonios ; Paramasivan, Poornima ; Troise, Antonio Dario ; Scaloni, Andrea ; Deeni, Yusuf ; Stephens, W. Edryd ; Fiore, Alberto. / Reducing toxic reactive carbonyl species in e-cigarette emissions : testing a harm-reduction strategy based on dicarbonyl trapping. In: RSC Advances. 2020 ; Vol. 10, No. 36. pp. 21535-21544.

Bibtex - Download

@article{a8d616b0077d4629a4f29d945642ca68,
title = "Reducing toxic reactive carbonyl species in e-cigarette emissions: testing a harm-reduction strategy based on dicarbonyl trapping",
abstract = "Reducing the concentration of reactive carbonyl species (RCS) in e-cigarette emissions represents a major goal to control their potentially harmful effects. Here, we adopted a novel strategy of trapping carbonyls present in e-cigarette emissions by adding polyphenols in e-liquid formulations. Our work showed that the addition of gallic acid, hydroxytyrosol and epigallocatechin gallate reduced the levels of carbonyls formed in the aerosols of vaped e-cigarettes, including formaldehyde, methylglyoxal and glyoxal. Liquid chromatography mass spectrometry analysis highlighted the formation of covalent adducts between aromatic rings and dicarbonyls in both e-liquids and vaped samples, suggesting that dicarbonyls were formed in the e-liquids as degradation products of propylene glycol and glycerol before vaping. Short-term cytotoxic analysis on two lung cellular models showed that dicarbonyl-polyphenol adducts are not cytotoxic, even though carbonyl trapping did not improve cell viability. Our work sheds lights on the ability of polyphenols to trap RCS in high carbonyl e-cigarette emissions, suggesting their potential value in commercial e-liquid formulations.",
author = "{de Falco}, Bruna and Antonios Petridis and Poornima Paramasivan and Troise, {Antonio Dario} and Andrea Scaloni and Yusuf Deeni and Stephens, {W. Edryd} and Alberto Fiore",
note = "The Carnegie Trust for the Universities of Scotland is thanked for providing funding to support this research (Grant Reference 50408).",
year = "2020",
month = jun,
day = "5",
doi = "10.1039/D0RA02138E",
language = "English",
volume = "10",
pages = "21535--21544",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "36",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Reducing toxic reactive carbonyl species in e-cigarette emissions

T2 - testing a harm-reduction strategy based on dicarbonyl trapping

AU - de Falco, Bruna

AU - Petridis, Antonios

AU - Paramasivan, Poornima

AU - Troise, Antonio Dario

AU - Scaloni, Andrea

AU - Deeni, Yusuf

AU - Stephens, W. Edryd

AU - Fiore, Alberto

N1 - The Carnegie Trust for the Universities of Scotland is thanked for providing funding to support this research (Grant Reference 50408).

PY - 2020/6/5

Y1 - 2020/6/5

N2 - Reducing the concentration of reactive carbonyl species (RCS) in e-cigarette emissions represents a major goal to control their potentially harmful effects. Here, we adopted a novel strategy of trapping carbonyls present in e-cigarette emissions by adding polyphenols in e-liquid formulations. Our work showed that the addition of gallic acid, hydroxytyrosol and epigallocatechin gallate reduced the levels of carbonyls formed in the aerosols of vaped e-cigarettes, including formaldehyde, methylglyoxal and glyoxal. Liquid chromatography mass spectrometry analysis highlighted the formation of covalent adducts between aromatic rings and dicarbonyls in both e-liquids and vaped samples, suggesting that dicarbonyls were formed in the e-liquids as degradation products of propylene glycol and glycerol before vaping. Short-term cytotoxic analysis on two lung cellular models showed that dicarbonyl-polyphenol adducts are not cytotoxic, even though carbonyl trapping did not improve cell viability. Our work sheds lights on the ability of polyphenols to trap RCS in high carbonyl e-cigarette emissions, suggesting their potential value in commercial e-liquid formulations.

AB - Reducing the concentration of reactive carbonyl species (RCS) in e-cigarette emissions represents a major goal to control their potentially harmful effects. Here, we adopted a novel strategy of trapping carbonyls present in e-cigarette emissions by adding polyphenols in e-liquid formulations. Our work showed that the addition of gallic acid, hydroxytyrosol and epigallocatechin gallate reduced the levels of carbonyls formed in the aerosols of vaped e-cigarettes, including formaldehyde, methylglyoxal and glyoxal. Liquid chromatography mass spectrometry analysis highlighted the formation of covalent adducts between aromatic rings and dicarbonyls in both e-liquids and vaped samples, suggesting that dicarbonyls were formed in the e-liquids as degradation products of propylene glycol and glycerol before vaping. Short-term cytotoxic analysis on two lung cellular models showed that dicarbonyl-polyphenol adducts are not cytotoxic, even though carbonyl trapping did not improve cell viability. Our work sheds lights on the ability of polyphenols to trap RCS in high carbonyl e-cigarette emissions, suggesting their potential value in commercial e-liquid formulations.

U2 - 10.1039/D0RA02138E

DO - 10.1039/D0RA02138E

M3 - Article

VL - 10

SP - 21535

EP - 21544

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 36

ER -

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