Skip to content

Research at St Andrews

Reversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchange

Research output: Contribution to journalArticle

Author(s)

Flavio della Sala, Euan Robert Kay

School/Research organisations

Abstract

Existing methods for the covalent functionalization of nanoparticles rely on kinetically controlled reactions, and largely lack the sophistication of the preeminent oligonucleotide-based noncovalent strategies. Here we report the application of dynamic covalent chemistry for the reversible modification of nanoparticle (NP) surface functionality, combining the benefits of non-biomolecular covalent chemistry with the favorable features of equilibrium processes. A homogeneous monolayer of nanoparticle-bound hydrazones can undergo quantitative dynamic covalent exchange. The pseudomolecular nature of the NP system allows for the in situ characterization of surface-bound species, and real-time tracking of the exchange reactions. Furthermore, dynamic covalent exchange offers a simple approach for reversibly switching—and subtly tuning—NP properties such as solvophilicity.
Close

Details

Original languageEnglish
Pages (from-to)4187–4191
JournalAngewandte Chemie International Edition
Volume54
Issue number14
Early online date14 Jan 2015
DOIs
Publication statusPublished - 27 Mar 2015

    Research areas

  • Dynamic covalent chemistry, Gold nanoparticles, Hydrazones, Supramolecular chemistry

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Programmable dynamic covalent nanoparticle building blocks with complementary reactivity

    Marro, N., della Sala, F. & Kay, E. R., 14 Nov 2019, In : Chemical Science. Advance Article

    Research output: Contribution to journalArticle

  2. Probing the interaction of nanoparticles with small molecules in real time via quartz crystal microbalance monitoring

    Yang, Y., Poss, G., Weng, Y., Qi, R., Zheng, H., Nianias, N., Kay, E. R. & Guldin, S., 21 Jun 2019, In : Nanoscale. 11, 23, p. 11107-11113 7 p.

    Research output: Contribution to journalArticle

  3. Twin-FRET: A New Molecular Ruler for Biomolecules

    Jana, S., Diez-Castellnou, M., Kay, E. R. & Penedo, C., 15 Feb 2019, In : Biophysical Journal. 116, 3, p. 565A-565A 1 p.

    Research output: Contribution to journalAbstract

  4. Optical trapping of ultrasmooth gold nanoparticles in liquid and air

    Arita, Y., Tkachenko, G., McReynolds, N., Marro, N., Edwards, W., Kay, E. R. & Dholakia, K., 25 Jun 2018, In : APL Photonics. 3, 8 p., 070801.

    Research output: Contribution to journalArticle

  5. Switchable selectivity within a series of boronate esters for dynamic covalent exchange in nonaqueous solvents

    Borsley, S., Poss, G., Spicer, R. L., Boudin, E. & Kay, E. R., 22 Feb 2018, In : Supramolecular Chemistry. Latest Articles, 10 p.

    Research output: Contribution to journalArticle

Related by journal

  1. High iso aldehyde selectivity in the hydroformylation of short-chain alkenes

    Iu, L., Fuentes, J. A., Janka, M., Fontenot, K. J. & Clarke, M. L., 11 Feb 2019, In : Angewandte Chemie International Edition. 58, 7, p. 2120-2124 5 p.

    Research output: Contribution to journalArticle

  2. Intramolecular borylation via sequential B-Mes bond cleavage for the divergent synthesis of B,N,B-doped benzo[4]helicenes

    Knöller, J., Meng, G., Wang, X., Hall, D., Pershin, A., Beljonne, D., Olivier, Y., Laschat, S., Zysman-Colman, E. & Wang, S., 31 Oct 2019, (Accepted/In press) In : Angewandte Chemie International Edition. In press

    Research output: Contribution to journalArticle

  3. Metal-organic framework-activated carbon composite materials for the removal of ammonia from contaminated airstreams

    McHugh, L. N., Terracina, A., Wheatley, P. S., Buscarino, G., Smith, M. W. & Morris, R. E., 19 Aug 2019, In : Angewandte Chemie International Edition. 58, 34, p. 11747-11751 5 p.

    Research output: Contribution to journalArticle

  4. Sub-micromolar pulse dipolar EPR spectroscopy reveals increasing CuII-labelling of double-histidine motifs with lower temperature

    Wort, J. L., Ackermann, K., Giannoulis, A., Stewart, A. J., Norman, D. G. & Bode, B. E., 19 Aug 2019, In : Angewandte Chemie - International Edition. 58, 34, p. 11681-11685 5 p.

    Research output: Contribution to journalArticle

ID: 167111236

Top