Skip to content

Research at St Andrews

Selective gating of neuronal activity by intrinsic properties in distinct motor rhythms

Research output: Contribution to journalArticle

DOI

Open Access permissions

Open

Abstract

Many neural circuits show fast reconfiguration following altered sensory or modulatory inputs to generate stereotyped outputs. In the motor circuit of Xenopus tadpoles, I study how certain voltage-dependent ionic currents affect firing thresholds and contribute to circuit reconfiguration to generate two distinct motor patterns, swimming and struggling. Firing thresholds of excitatory interneurons [i.e., descending interneurons (dINs)] in the swimming central pattern generator are raised by depolarization due to the inactivation of Na+ currents. In contrast, the thresholds of other types of neurons active in swimming or struggling are raised by hyperpolarization from the activation of fast transient K+ currents. The firing thresholds are then compared with the excitatory synaptic drives, which are revealed by blocking action potentials intracellularly using QX314 during swimming and struggling. During swimming, transient K+ currents lower neuronal excitability and gate out neurons with weak excitation, whereas their inactivation by strong excitation in other neurons increases excitability and enables fast synaptic potentials to drive reliable firing. During struggling, continuous sensory inputs lead to high levels of network excitation. This allows the inactivation of Na+ currents and suppression of dIN activity while inactivating transient K+ currents, recruiting neurons that are not active in swimming. Therefore, differential expression of these currents between neuron types can explain why synaptic strength does not predict firing reliability/intensity during swimming and struggling. These data show that intrinsic properties can override fast synaptic potentials, mediate circuit reconfiguration, and contribute to motor–pattern switching.
Close

Details

Original languageEnglish
Pages (from-to)9799-9810
JournalThe Journal of Neuroscience
Volume35
Issue number27
DOIs
StatePublished - 8 Jul 2015

    Research areas

  • Central pattern generation, Intrinsic property, Locomotion, Spinal cord, Struggling, Swimming

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. To swim or not to swim: a population-level model of Xenopus tadpole decision making and locomotor behaviour

    Borisyuk, R., Merrison-Hort, R., Soffe, S. R., Koutsikou, S. & Li, W-C. 15 Jul 2017 In : Aquatic Biosystems. In press

    Research output: Contribution to journalArticle

  2. The modulation of two motor behaviors by persistent sodium currents in Xenopus laevis tadpoles

    Svensson, E., Jeffreys, H. & Li, W. 1 Jul 2017 In : Journal of Neurophysiology. 118, 1, p. 121-130

    Research output: Contribution to journalArticle

  3. Electrical coupling in the generation of vertebrate motor rhythms

    Li, W. & Rekling, J. 2017 Network functions and plasticity: perspectives from studying neuronal electrical coupling in microcircuits. Jing, J. (ed.). Elsevier Inc., p. 243-265

    Research output: Chapter in Book/Report/Conference proceedingChapter

  4. Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish

    Raghupathy, R. K., Zhang, X., Alhasani, R. H., Zhou, X., Mullin, M., Reilly, J., Li, W., Liu, M. & Shu, X. 25 Aug 2016 In : Cell Biochemistry and Function. 34, 6, p. 429-440 12 p.

    Research output: Contribution to journalArticle

Related by journal

  1. Sodium pumps mediate activity-dependent changes in mammalian motor networks

    Picton, L. D., Nascimento, F., Broadhead, M. J., Sillar, K. T. & Miles, G. B. 25 Jan 2017 In : The Journal of Neuroscience. 37, 4, p. 906-921 16 p.

    Research output: Contribution to journalArticle

  2. Expression of an activated integrin promotes long-distance sensory axon regeneration in the spinal cord

    Cheah, M., Andrews, M. R., Chew, D., Moloney, E., Verhaagen, J., Fassler, R. & Fawcett, J. 6 Jul 2016 In : The Journal of Neuroscience. 36, 27, p. 7283-7297 15 p.

    Research output: Contribution to journalArticle

  3. Deep brain stimulation of different pedunculopontine targets in a novel rodent model of parkinsonism

    Gut, N. K. & Winn, P. 25 Mar 2015 In : The Journal of Neuroscience. 35, 12, p. 4792-4803 12 p.

    Research output: Contribution to journalArticle

  4. The generation of antiphase oscillations and synchrony by a rebound-based vertebrate central pattern generator

    Li, W., Merrison-Hort, R., Zhang, H. Y. & Borisyuk, R. 23 Apr 2014 In : The Journal of Neuroscience. 34, 17, p. 6065-77 13 p.

    Research output: Contribution to journalArticle

ID: 189029154