Skip to content

Research at St Andrews

Selective inhibition mediates the sequential recruitment of motor pools

Research output: Contribution to journalArticle

Author(s)

Maarten F. Zwart, Stefan R. Pulver, James W. Truman, Akira Fushiki, Richard D. Fetter, Albert Cardona, Matthias Landgraf

School/Research organisations

Abstract

Locomotor systems generate diverse motor patterns to produce the movements underlying behavior, requiring that motor neurons be recruited at various phases of the locomotor cycle. Reciprocal inhibition produces alternating motor patterns; however, the mechanisms that generate other phasic relationships between intrasegmental motor pools are unknown. Here, we investigate one such motor pattern in the . Drosophila larva, using a multidisciplinary approach including electrophysiology and ssTEM-based circuit reconstruction. We find that two motor pools that are sequentially recruited during locomotion have identical excitable properties. In contrast, they receive input from divergent premotor circuits. We find that this motor pattern is not orchestrated by differential excitatory input but by a GABAergic interneuron acting as a delay line to the later-recruited motor pool. Our findings show how a motor pattern is generated as a function of the modular organization of locomotor networks through segregation of inhibition, a potentially general mechanism for sequential motor patterns. How locomotor systems generate overlapping sequences of local muscle contractions is unknown. Zwart et al. show in the . Drosophila larva that an inhibitory neuron acts as a delay line to a specific population of motor neurons to generate such a sequence.

Close

Details

Original languageEnglish
Pages (from-to)615-628
Number of pages14
JournalNeuron
Volume91
Issue number3
Early online date14 Jul 2016
DOIs
StatePublished - Aug 2016

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Selective inhibition mediates the sequential recruitment of motor pools: Correction

    Zwart, M. F., Pulver, S., Truman, J., Fushiki, A., Cardona, A. & Landgraf, M. 17 Aug 2016 In : Neuron. 91, 4, p. 944

    Research output: Contribution to journalArticle

  2. Organic light-emitting diodes for optogenetic stimulation of Drosophila larvae

    Murawski, C., Morton, A., Samuel, I. D. W., Pulver, S. & Gather, M. C. 14 Nov 2016 Proceedings, Light, Energy and the Environment. Optical Society of American (OSA), 3 p. JW4A.9. (Fourier Transform Spectroscopy)

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  3. The serotonergic system tracks the outcomes of actions to mediate short-term motor learning

    Kawashima, T., Zwart, M. F., Yang, C-T., Mensh, B. & Ahrens, M. 3 Nov 2016 In : Cell. 167, 4, p. 933-946 e20

    Research output: Contribution to journalArticle

  4. Quantitative neuroanatomy for connectomics in Drosophila

    Schneider-Mizell, C., Gerhard, S., Longair, M., Kazimiers, T., Li, F., Zwart, M. F., Champion, A., Midgley, F., Fetter, R., Saalfeld, S. & Cardona, A. 30 Sep 2016 In : eLife. 5, 36 p., e12059

    Research output: Contribution to journalArticle

Related by journal

  1. Selective inhibition mediates the sequential recruitment of motor pools: Correction

    Zwart, M. F., Pulver, S., Truman, J., Fushiki, A., Cardona, A. & Landgraf, M. 17 Aug 2016 In : Neuron. 91, 4, p. 944

    Research output: Contribution to journalArticle

  2. Even-skipped+ interneurons are core components of a sensorimotor circuit that maintains left-right symmetric muscle contraction amplitude

    Heckscher, E., Zarin, A., Faumont, S., Clark, M., Manning, L., Fushiki, A., Schneider-Mizell, C., Fetter, R. D., Truman, J., Zwart, M. F., Landgraf, M., Cardona, A., Lockery, S. & Doe, C. 21 Oct 2015 In : Neuron. 88, 2, p. 314-329

    Research output: Contribution to journalArticle

  3. Fast silencing reveals a lost role for reciprocal inhibition in locomotion

    Moult, P. R., Cottrell, G. A. & Li, W. 9 Jan 2013 In : Neuron. 77, 1, p. 129-140 12 p.

    Research output: Contribution to journalArticle

  4. The best things come in small packages- vesicular delivery of weak base antipsychotics

    Morton, A. & Cousin, M. A. 7 Jun 2012 In : Neuron. 74, 5, p. 765-7 3 p.

    Research output: Contribution to journalArticle

ID: 244761186