Skip to content

Research at St Andrews

Selective inhibition mediates the sequential recruitment of motor pools

Research output: Contribution to journalArticlepeer-review

Author(s)

Maarten F. Zwart, Stefan R. Pulver, James W. Truman, Akira Fushiki, Richard D. Fetter, Albert Cardona, Matthias Landgraf

School/Research organisations

Abstract

Locomotor systems generate diverse motor patterns to produce the movements underlying behavior, requiring that motor neurons be recruited at various phases of the locomotor cycle. Reciprocal inhibition produces alternating motor patterns; however, the mechanisms that generate other phasic relationships between intrasegmental motor pools are unknown. Here, we investigate one such motor pattern in the Drosophila larva, using a multidisciplinary approach including electrophysiology and ssTEM-based circuit reconstruction. We find that two motor pools that are sequentially recruited during locomotion have identical excitable properties. In contrast, they receive input from divergent premotor circuits. We find that this motor pattern is not orchestrated by differential excitatory input but by a GABAergic interneuron acting as a delay line to the later-recruited motor pool. Our findings show how a motor pattern is generated as a function of the modular organization of locomotor networks through segregation of inhibition, a potentially general mechanism for sequential motor patterns.

Close

Details

Original languageEnglish
Pages (from-to)615-628
Number of pages14
JournalNeuron
Volume91
Issue number3
Early online date14 Jul 2016
DOIs
Publication statusPublished - 3 Aug 2016

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Selective inhibition mediates the sequential recruitment of motor pools: Correction

    Zwart, M. F., Pulver, S., Truman, J., Fushiki, A., Cardona, A. & Landgraf, M., 17 Aug 2016, In: Neuron. 91, 4, p. 944

    Research output: Contribution to journalArticlepeer-review

  2. An electrically coupled pioneer circuit enables motor development via proprioceptive feedback in Drosophila embryos

    Zeng, X., Komanome, Y., Kawasaki, T., Inada, K., Jonaitis, J., Pulver, S. R., Kazama, H. & Nose, A., 18 Oct 2021, (E-pub ahead of print) In: Current Biology. In press

    Research output: Contribution to journalArticlepeer-review

  3. Regulation of coordinated muscular relaxation in Drosophila larvae by a pattern-regulating intersegmental circuit

    Hiramoto, A., Jonaitis, J., Niki, S., Kohsaka, H., Fetter, R. D., Cardona, A., Pulver, S. R. & Nose, A., 19 May 2021, In: Nature Communications. 12, 14 p., 2943.

    Research output: Contribution to journalArticlepeer-review

  4. Inexpensive methods for live imaging of central pattern generator activity in the Drosophila larval locomotor system

    Booth, J., Sane, V., Gather, M. C. & Pulver, S. R., 31 Dec 2020, In: Journal of Undergraduate Neuroscience Education. 19, 1, p. A124-A133

    Research output: Contribution to journalArticlepeer-review

  5. Segment-specific optogenetic stimulation in Drosophila melanogaster with linear arrays of organic light-emitting diodes

    Murawski, C., Pulver, S. R. & Gather, M. C., 7 Dec 2020, In: Nature Communications. 11, 11 p., 6248.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. A Modular Approach to Vocal Learning: Disentangling the Diversity of a Complex Behavioral Trait

    Wirthlin, M., Chang, E. F., Knörnschild, M., Krubitzer, L. A., Mello, C. V., Miller, C. T., Pfenning, A. R., Vernes, S. C., Tchernichovski, O. & Yartsev, M. M., 9 Oct 2019, In: Neuron. 104, 1, p. 87-99 13 p.

    Research output: Contribution to journalReview articlepeer-review

  2. An open resource for non-human primate imaging

    Milham, M. P., Ai, L., Koo, B., Xu, T., Amiez, C., Balezeau, F., Baxter, M. G., Blezer, E. L. A., Brochier, T., Chen, A., Croxson, P. L., Damatac, C. G., Dehaene, S., Everling, S., Fair, D. A., Fleysher, L., Freiwald, W., Froudist-Walsh, S., Griffiths, T. D., Guedj, C. & 50 others, Hadj-Bouziane, F., Ben Hamed, S., Harel, N., Hiba, B., Jarraya, B., Jung, B., Kastner, S., Klink, P. C., Kwok, S. C., Laland, K. N., Leopold, D. A., Lindenfors, P., Mars, R. B., Menon, R. S., Messinger, A., Meunier, M., Mok, K., Morrison, J. H., Nacef, J., Nagy, J., Rios, M. O., Petkov, C. I., Pinsk, M., Poirier, C., Procyk, E., Rajimehr, R., Reader, S. M., Roelfsema, P. R., Rudko, D. A., Rushworth, M. F. S., Russ, B. E., Sallet, J., Schmid, M. C., Schwiedrzik, C. M., Seidlitz, J., Sein, J., Shmuel, A., Sullivan, E. L., Ungerleider, L., Thiele, A., Todorov, O. S., Tsao, D., Wang, Z., Wilson, C. R. E., Yacoub, E., Ye, F. Q., Zarco, W., Zhou, Y., Margulies, D. S. & Schroeder, C. E., 10 Oct 2018, In: Neuron. 100, 1, p. 61-74 e2.

    Research output: Contribution to journalArticlepeer-review

  3. Selective inhibition mediates the sequential recruitment of motor pools: Correction

    Zwart, M. F., Pulver, S., Truman, J., Fushiki, A., Cardona, A. & Landgraf, M., 17 Aug 2016, In: Neuron. 91, 4, p. 944

    Research output: Contribution to journalArticlepeer-review

  4. Even-skipped+ interneurons are core components of a sensorimotor circuit that maintains left-right symmetric muscle contraction amplitude

    Heckscher, E., Zarin, A., Faumont, S., Clark, M., Manning, L., Fushiki, A., Schneider-Mizell, C., Fetter, R. D., Truman, J., Zwart, M. F., Landgraf, M., Cardona, A., Lockery, S. & Doe, C., 21 Oct 2015, In: Neuron. 88, 2, p. 314-329

    Research output: Contribution to journalArticlepeer-review

ID: 244761186

Top