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Selectively fluorinated cyclohexane building blocks: derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane

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Abstract

Palladium catalysed carbonylation reactions using the meta- and para-iodo derivatives of all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane (4) are illustrated as the start point for a variety of functional group interconversions. The resultant benzaldehyde and benzoic acids offer novel building blocks for further derivatisation and facilitate the incorporation of the facially polarised all-cis-1,2,4,5-tetrafluorocyclohexane motif into more advanced molecular scaffolds.

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Original languageEnglish
Pages (from-to)2671-2676
Number of pages6
JournalBeilstein Journal of Organic Chemistry
Volume11
DOIs
Publication statusPublished - 21 Dec 2015

    Research areas

  • Cyclohexane carbonylation, Fluorine containing building blocks: organofluorine chemistry

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