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Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

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Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. / Da Cunha, Violette; Davies, Mark R; Douarre, Pierre-Emmanuel; Rosinski-Chupin, Isabelle; Margarit, Immaculada; Spinali, Sebastien; Perkins, Tim; Lechat, Pierre; Dmytruk, Nicolas; Sauvage, Elisabeth; Ma, Laurence; Romi, Benedetta; Tichit, Magali; Lopez-Sanchez, Maria-José; Descorps-Declere, Stéphane; Souche, Erika; Buchrieser, Carmen; Trieu-Cuot, Patrick; Moszer, Ivan; Clermont, Dominique; Maione, Domenico; Bouchier, Christiane; McMillan, David J; Parkhill, Julian; Telford, John L; Dougan, Gordan; Walker, Mark J; Holden, Matthew T G; Poyart, Claire; Glaser, Philippe; DEVANI Consortium.

In: Nature Communications, Vol. 5, 2014, p. 4544.

Research output: Contribution to journalArticle

Harvard

Da Cunha, V, Davies, MR, Douarre, P-E, Rosinski-Chupin, I, Margarit, I, Spinali, S, Perkins, T, Lechat, P, Dmytruk, N, Sauvage, E, Ma, L, Romi, B, Tichit, M, Lopez-Sanchez, M-J, Descorps-Declere, S, Souche, E, Buchrieser, C, Trieu-Cuot, P, Moszer, I, Clermont, D, Maione, D, Bouchier, C, McMillan, DJ, Parkhill, J, Telford, JL, Dougan, G, Walker, MJ, Holden, MTG, Poyart, C, Glaser, P & DEVANI Consortium 2014, 'Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline', Nature Communications, vol. 5, pp. 4544. https://doi.org/10.1038/ncomms5544

APA

Da Cunha, V., Davies, M. R., Douarre, P-E., Rosinski-Chupin, I., Margarit, I., Spinali, S., ... DEVANI Consortium (2014). Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nature Communications, 5, 4544. https://doi.org/10.1038/ncomms5544

Vancouver

Da Cunha V, Davies MR, Douarre P-E, Rosinski-Chupin I, Margarit I, Spinali S et al. Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nature Communications. 2014;5:4544. https://doi.org/10.1038/ncomms5544

Author

Da Cunha, Violette ; Davies, Mark R ; Douarre, Pierre-Emmanuel ; Rosinski-Chupin, Isabelle ; Margarit, Immaculada ; Spinali, Sebastien ; Perkins, Tim ; Lechat, Pierre ; Dmytruk, Nicolas ; Sauvage, Elisabeth ; Ma, Laurence ; Romi, Benedetta ; Tichit, Magali ; Lopez-Sanchez, Maria-José ; Descorps-Declere, Stéphane ; Souche, Erika ; Buchrieser, Carmen ; Trieu-Cuot, Patrick ; Moszer, Ivan ; Clermont, Dominique ; Maione, Domenico ; Bouchier, Christiane ; McMillan, David J ; Parkhill, Julian ; Telford, John L ; Dougan, Gordan ; Walker, Mark J ; Holden, Matthew T G ; Poyart, Claire ; Glaser, Philippe ; DEVANI Consortium. / Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. In: Nature Communications. 2014 ; Vol. 5. pp. 4544.

Bibtex - Download

@article{a0af8f2fdb4b4b11bfe2ca19fc3a1e43,
title = "Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline",
abstract = "Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.",
author = "{Da Cunha}, Violette and Davies, {Mark R} and Pierre-Emmanuel Douarre and Isabelle Rosinski-Chupin and Immaculada Margarit and Sebastien Spinali and Tim Perkins and Pierre Lechat and Nicolas Dmytruk and Elisabeth Sauvage and Laurence Ma and Benedetta Romi and Magali Tichit and Maria-Jos{\'e} Lopez-Sanchez and St{\'e}phane Descorps-Declere and Erika Souche and Carmen Buchrieser and Patrick Trieu-Cuot and Ivan Moszer and Dominique Clermont and Domenico Maione and Christiane Bouchier and McMillan, {David J} and Julian Parkhill and Telford, {John L} and Gordan Dougan and Walker, {Mark J} and Holden, {Matthew T G} and Claire Poyart and Philippe Glaser and {DEVANI Consortium}",
year = "2014",
doi = "10.1038/ncomms5544",
language = "English",
volume = "5",
pages = "4544",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature publishing group",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

AU - Da Cunha, Violette

AU - Davies, Mark R

AU - Douarre, Pierre-Emmanuel

AU - Rosinski-Chupin, Isabelle

AU - Margarit, Immaculada

AU - Spinali, Sebastien

AU - Perkins, Tim

AU - Lechat, Pierre

AU - Dmytruk, Nicolas

AU - Sauvage, Elisabeth

AU - Ma, Laurence

AU - Romi, Benedetta

AU - Tichit, Magali

AU - Lopez-Sanchez, Maria-José

AU - Descorps-Declere, Stéphane

AU - Souche, Erika

AU - Buchrieser, Carmen

AU - Trieu-Cuot, Patrick

AU - Moszer, Ivan

AU - Clermont, Dominique

AU - Maione, Domenico

AU - Bouchier, Christiane

AU - McMillan, David J

AU - Parkhill, Julian

AU - Telford, John L

AU - Dougan, Gordan

AU - Walker, Mark J

AU - Holden, Matthew T G

AU - Poyart, Claire

AU - Glaser, Philippe

AU - DEVANI Consortium

PY - 2014

Y1 - 2014

N2 - Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.

AB - Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.

U2 - 10.1038/ncomms5544

DO - 10.1038/ncomms5544

M3 - Article

VL - 5

SP - 4544

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -

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