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Synthesis and properties of mechanism-based inhibitors and probes for inositol monophosphatase derived from 6-O-(2′-hydroxyethyl)-(1R,2R,4R,6R)- cyclohexane-1,2,4,6-tetraol

Research output: Contribution to journalArticlepeer-review

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Author(s)

Jürgen Schulz, John Wilkie, Philip Lightfoot, Trevor Rutherford, David Gani

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Abstract

The 1-phosphate, 2′-phosphate and 1,2′-cyclic phosphate of 6-O-(2-hydroxyethyl)-cyclohexane-1,2,4,6-tetraol are synthesised and found to be good inhibitors of inositol monophosphatase; the stereochemistry of the most potent inhibitor, the (1R,2R,4R,6R)-1-phosphate, provides useful mechanistic insight into the action of this enzyme, the putative target for lithium therapy.

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Original languageEnglish
Pages (from-to)2353-2356
Number of pages4
JournalJournal of the Chemical Society, Chemical Communications
Issue number22
DOIs
Publication statusPublished - 1 Dec 1995

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