Skip to content

Research at St Andrews

Synthesis of Poly(ethylene oxide) Approaching Monodispersity

Research output: Contribution to journalArticlepeer-review

DOI

Author(s)

Krzysztof Maranski, Yuri G. Andreev, Peter G. Bruce

School/Research organisations

Abstract

Polydispersity in polymers hinders fundamental understanding of their structure-property relationships and prevents them from being used in fields like medicine, where polydispersity affects biological activity. The polydispersity of relatively short-chain poly(ethylene oxide) [(CH2CH2O2)(n); PEO] affects its biological activity, for example, the toxicity and efficacy of PEOylated drugs. As a result, there have been intensive efforts to reduce the dispersity as much as possible (truly monodispersed materials are not possible). Here we report a synthetic procedure that leads to an unprecedented low level of dispersity. We also show for the first time that it is possible to discriminate between PEOs differing in only 1 ethylene oxide (EO) unit, essential in order to verify the exceptionally low levels of dispersity achieved here. It is anticipated that the synthesis of poly(ethylene oxide) approaching monodispersity will be of value in many fields where the applications are sensitive to the distribution of molar mass.

Close

Details

Original languageEnglish
Pages (from-to)6411-6413
Number of pages3
JournalAngewandte Chemie International Edition
Volume53
Issue number25
DOIs
Publication statusPublished - Jun 2014

    Research areas

  • mass spectrometry, monodispersity, polyethers, polymers (org.), FLIGHT MASS-SPECTROMETRY, MOLECULAR-WEIGHT, POLYMERS, GLYCOL), TIME

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Na0.35MnO2 as an ionic conductor with randomly distributed nano-sized layers

    Adomkevicius, A., Cabo-Fernandez, L., Wu, T-H., Ou, T-M., Chen, M-G., Andreev, Y., Hu, C-C. & Hardwick, L. J., 28 May 2017, In: Journal of Materials Chemistry A. 5, 20, p. 10021-10026

    Research output: Contribution to journalArticlepeer-review

  2. Size and shape of graphene layers in commercial carbon blacks established by Debye refinement

    Andreev, Y. G. & Bruce, P., Feb 2016, In: Journal of Applied Crystallography. 49, 1, p. 24-30

    Research output: Contribution to journalArticlepeer-review

  3. Crystalline polymer electrolytes

    Andreev, Y. G., Zhang, C. & Bruce, FRS, P., Aug 2015, Handbook of Solid State Batteries. Dudney, N. J., West, W. C. & Nanda, J. (eds.). 2nd ed. World Scientific Publishing Co. Pte Ltd, p. 503-522 (Materials and Energy; vol. 6).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  4. The Shape of TiO2-B Nanoparticles

    Andreev, Y. G., Panchmatia, P. M., Liu, Z., Parker, S. C., Islam, M. S. & Bruce, P. G., 30 Apr 2014, In: Journal of the American Chemical Society. 136, 17, p. 6306-6312 7 p.

    Research output: Contribution to journalArticlepeer-review

  5. Nanostructured TiO2(B): the effect of size and shape on anode properties for Li-ion batteries

    Liu, Z., Andreev, Y. G., Armstrong, A. R., Brutti, S., Ren, Y. & Bruce, P. G., Jun 2013, In: Progress in Natural Science: Materials International. 23, 3, p. 235-244 10 p.

    Research output: Contribution to journalReview articlepeer-review

Related by journal

  1. Enantioselective synthesis of α-aryl-β2-amino-esters by cooperative isothiourea and Brønsted acid catalysis

    Zhao, F., Shu, C., Young, C. M., Carpenter-Warren, C., Slawin, A. M. Z. & Smith, A. D., 11 May 2021, In: Angewandte Chemie International Edition. 60, 21, p. 11892-11900 10 p.

    Research output: Contribution to journalArticlepeer-review

  2. Using the mechanical bond to tune the performance of a thermally activated delayed fluorescence emitter

    Rajamalli, P., Rizzi, F., Li, W., Jinks, M. A., Gupta, A. K., Laidlaw, B., Samuel, I. D. W., Penfold, T. J., Goldup, S. M. & Zysman-Colman, E., 11 May 2021, In: Angewandte Chemie International Edition. 60, 21, p. 12066-12073 9 p.

    Research output: Contribution to journalArticlepeer-review

  3. Engineering of a peptide α-N-methyltransferase to methylate non-proteinogenic amino acids

    Song, H., Burton, A. J., Shirran, S. L., Fahrig-Kamarauskaitė, J., Kaspar, H., Muir, T. W., Künzler, M. & Naismith, J. H., 15 Apr 2021, (E-pub ahead of print) In: Angewandte Chemie International Edition. Early View, 6 p.

    Research output: Contribution to journalArticlepeer-review

  4. Cu(OTf)2-mediated cross-coupling of nitriles and N-heterocycles with arylboronic acids to generate nitrilium and pyridinium products

    Bell, N., Xu, C., Fyfe, J., Vantourout, J. C., Brals, J., Chabbra, S., Bode, B. E., Cordes, D. B., Slawin, A. M. Z., McGuire, T. M. & Watson, A. J. B., 29 Mar 2021, In: Angewandte Chemie International Edition. 60, 14, p. 7935-7940 7 p.

    Research output: Contribution to journalArticlepeer-review

  5. Janus face all-cis 1,2,4,5-tetrakis(trifluoromethyl)- and all-cis 1,2,3,4,5,6-hexakis(trifluoromethyl)- cyclohexanes

    Yu, C., Kütt, A., Röschenthaler, G-V., Lebl, T., Cordes, D. B., Slawin, A. M. Z., Buehl, M. & O'Hagan, D., 26 Oct 2020, In: Angewandte Chemie International Edition. 59, 45, p. 19905-19909 5 p.

    Research output: Contribution to journalArticlepeer-review

ID: 134485328

Top