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Technical assessment of whole body angiography and cardiac function within a single MRI examination

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Author(s)

S. J. Gandy, M. Lambert, J. J.F. Belch, I. D. Cavin, E. Crowe, R. Littleford, J. A. Macfarlane, S. Z. Matthew, P. Martin, R. S. Nicholas, A. D. Struthers, F. Sullivan, S. A. Waugh, R. D. White, J. R. Weir-Mccall, J. G. Houston

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Abstract

Aim To evaluate a combined protocol for simultaneous cardiac MRI (CMR) and contrast-enhanced (CE) whole-body MR angiography (WB-MRA) techniques within a single examination. Materials and methods Asymptomatic volunteers (n = 48) with low-moderate risk of cardiovascular disease (CVD) were recruited. The protocol was divided into four sections: (1) CMR of left ventricle (LV) structure and function; (2) CE-MRA of the head, neck, and thorax followed by the distal lower limbs; (3) CMR LV "late gadolinium enhancement" assessment; and (4) CE-MRA of the abdomen and pelvis followed by the proximal lower limbs. Multiple observers undertook the image analysis. Results For CMR, the mean ejection fraction (EF) was 67.3 ± 4.8% and mean left ventricular mass (LVM) was 100.3 ± 22.8 g. The intra-observer repeatability for EF ranged from 2.1-4.7% and from 9-12 g for LVM. Interobserver repeatability was 8.1% for EF and 19.1 g for LVM. No LV delayed myocardial enhancement was observed. For WB-MRA, some degree of luminal narrowing or stenosis was seen at 3.6% of the vessel segments (involving n = 29 of 48 volunteers) and interobserver radiological opinion was consistent in 96.7% of 1488 vessel segments assessed. Conclusion Combined assessment of WB-MRA and CMR can be undertaken within a single examination on a clinical MRI system. The associated analysis techniques are repeatable and may be suitable for larger-scale cardiovascular MRI studies.

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Original languageEnglish
Pages (from-to)595-603
Number of pages9
JournalClinical Radiology
Volume70
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015

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