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The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain

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Agnieszka Swiatek, Stuart Andrew MacNeill

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Abstract

Primase and GINS are essential factors for chromosomal DNA replication in eukaryotic and archaeal cells. Here we describe a previously undetected relationship between the C-terminal domain of the catalytic subunit (PriS) of archaeal primase and the B-domains of the archaeo-eukaryotic GINS proteins in the form of a conserved structural domain comprising a three-stranded antiparallel beta-sheet adjacent to an alpha-helix and a two-stranded beta-sheet or hairpin. The presence of a shared domain in archaeal PriS and GINS proteins, the genes for which are often found adjacent on the chromosome, suggests simple mechanisms for the evolution of these proteins.
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Original languageEnglish
Pages (from-to)17
Number of pages6
JournalBiology Direct
Volume5
Issue number1
DOIs
StatePublished - 12 Apr 2010

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