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The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain

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Agnieszka Swiatek, Stuart Andrew MacNeill

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Primase and GINS are essential factors for chromosomal DNA replication in eukaryotic and archaeal cells. Here we describe a previously undetected relationship between the C-terminal domain of the catalytic subunit (PriS) of archaeal primase and the B-domains of the archaeo-eukaryotic GINS proteins in the form of a conserved structural domain comprising a three-stranded antiparallel beta-sheet adjacent to an alpha-helix and a two-stranded beta-sheet or hairpin. The presence of a shared domain in archaeal PriS and GINS proteins, the genes for which are often found adjacent on the chromosome, suggests simple mechanisms for the evolution of these proteins.


Original languageEnglish
Pages (from-to)17
Number of pages6
JournalBiology Direct
Issue number1
StatePublished - 12 Apr 2010

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