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The Cajal body and the nucleolus: “in a relationship” or “it's complicated”?

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From their initial identification as 'nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy. In this review, we seek to place recent developments in the understanding of the physical and functional relationships between the two structures in the context of historical observations. Biophysical models of nuclear body formation, the molecular nature of CB/nucleolus interactions and the increasing list of joint roles for CBs and nucleoli, predominantly in assembling ribonucleoprotein (RNP) complexes, are discussed.


Original languageEnglish
Pages (from-to)739-751
JournalRNA Biology
Issue number6
Early online date23 Sep 2016
StatePublished - 2017

    Research areas

  • Nucleolus, Cajal body, snoRNPs, snRNPs, Non-coding RNAs, Telomerase, Phase separation, Nuclear structure, Nuclear bodies, Coilin

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