Skip to content

Research at St Andrews

The Cajal body and the nucleolus: “in a relationship” or “it's complicated”?

Research output: Contribution to journalReview articlepeer-review

Abstract

From their initial identification as 'nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy. In this review, we seek to place recent developments in the understanding of the physical and functional relationships between the two structures in the context of historical observations. Biophysical models of nuclear body formation, the molecular nature of CB/nucleolus interactions and the increasing list of joint roles for CBs and nucleoli, predominantly in assembling ribonucleoprotein (RNP) complexes, are discussed.
Close

Details

Original languageEnglish
Pages (from-to)739-751
JournalRNA Biology
Volume14
Issue number6
Early online date23 Sep 2016
DOIs
Publication statusPublished - 2017

    Research areas

  • Nucleolus, Cajal body, snoRNPs, snRNPs, Non-coding RNAs, Telomerase, Phase separation, Nuclear structure, Nuclear bodies, Coilin

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology

    Thompson, L. W., Morrison, K. D., Shirran, S. L., Groen, E. J. N., Gillingwater, T. H., Botting, C. H. & Sleeman, J. E., 17 Apr 2018, In: Journal of Cell Science. 131, 8, 18 p., jcs211482.

    Research output: Contribution to journalArticlepeer-review

  2. Nuclear bodies: new insights into assembly/dynamics and disease relevance

    Sleeman, J. E. & Trinkle-Mulcahy, L., Jun 2014, In: Current Opinion in Cell Biology. 28, p. 76-83 8 p.

    Research output: Contribution to journalArticlepeer-review

  3. Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1

    Coleman, S., Prescott, A. R. & Sleeman, J. E., 1 Mar 2014, In: Biochemical Journal. 458, 2, p. 267-280 13 p.

    Research output: Contribution to journalArticlepeer-review

  4. Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking

    Prescott, A. R., Bales, A., James, J., Trinkle-Mulcahy, L. & Sleeman, J. E., 14 Feb 2014, In: Journal of Cell Science. 127, 4, p. 812-827 15 p.

    Research output: Contribution to journalArticlepeer-review

  5. Small nuclear RNAs and mRNAs: linking RNA processing and transport to spinal muscular atrophy

    Sleeman, J., Aug 2013, In: Biochemical Society Transactions. 41, 4, p. 871-875 5 p.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. Structure of the archaeal Cascade subunit Csa5: Relating the small subunits of CRISPR effector complexes

    Reeks, J. A., Graham, S., Anderson, L., Liu, H., White, M. F. & Naismith, J., May 2013, In: RNA Biology. 10, 5, p. 762-769 8 p.

    Research output: Contribution to journalArticlepeer-review

  2. Folding of the SAM-I riboswitch: A tale with a twist

    Eschbach, SH., St-Pierre, P., Penedo, C. & Lafontaine, DA., Apr 2012, (Accepted/In press) In: RNA Biology. 9, 2

    Research output: Contribution to journalReview articlepeer-review

ID: 246305059

Top