Skip to content

Research at St Andrews

The complete nucleotide sequence of enterovirus type 70: Relationships with other members of the picornaviridae

Research output: Contribution to journalArticlepeer-review

Author(s)

M. D. Ryan, O. Jenkins, P. J. Hughes, A. Brown, N. J. Knowles, D. Booth, P. D. Minor, J. W. Almond

School/Research organisations

Abstract

Enterovirus type 70 (EV70) is the causative agent of acute haemorrhagic conjunctivitis and may also give rise to a rare neurological complication closely resembling poliomyelitis. The complete nucleotide sequence of the genome of EV70 has been determined from cDNA cloned in Escherichia coli. The genome consists of a 5' non-coding region of 726 nucleotides (nt), a long open reading frame of 6582 nt and a 3' non-coding region of 82 nt prior to the poly(A) tract. Comparison of the nucleotide sequence and the predicted amino acid sequence of the polyprotein with those published for other enteroviruses reveals sufficiently high similarity to predict antigenic regions and polyprotein cleavage sites. The P1 region of EV70 is as similar to those of the entero- as to those of the rhinoviruses, whereas the P2 and P3 regions are more closely related to the coxsackie B and swine vesicular disease viruses than other entero- or rhinoviruses.

Close

Details

Original languageEnglish
Pages (from-to)2291-2299
Number of pages9
JournalJournal of General Virology
Volume71
Issue number10
DOIs
Publication statusPublished - 1 Jan 1990

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Expression and immunogenicity of secreted forms of bovine ephemeral fever virus glycoproteins applied to subunit vaccine development

    Lo, Y-T., Tulloch, F., Wu, H-C., Luke, G. A., Ryan, M. D. & Chu, C-Y., 18 Feb 2021, (Accepted/In press) In: Journal of Applied Microbiology.

    Research output: Contribution to journalArticlepeer-review

  2. A transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system

    Grabert, K., Sehgal, A., Irvine, K. M., Wollscheid-Lengeling, E., Ozdemir, D. D., Stables, J., Luke, G. A., Ryan, M. D., Adamson, A., Humphreys, N. E., Sandrock, C. J., Rojo, R., Verkasalo, V. A., Mueller, W., Hohenstein, P., Pettit, A. R., Pridans, C. & Hume, D. A., 1 Dec 2020, In: The Journal of Immunology. 205, 11

    Research output: Contribution to journalArticlepeer-review

  3. Restoration of damaged dental enamels using nano-scale iron-calcium phosphate minerals and femto-second pulsed near-IR lasers

    Anastasiou, A. D., Strafford, S., Edwards, T. J., Malinowski, M., Brown, C. T. A., Routledge, M. N., Brown, A. P., Duggal, M. S. & Jha, A., 17 Oct 2019, 2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2019. Institute of Electrical and Electronics Engineers Inc., 8872675. (2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2019).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  4. Therapeutic applications of the 'NPGP' family of viral 2As

    Luke, G. A. & Ryan, M. D., Nov 2018, In: Reviews in Medical Virology. 28, 6, 12 p., e2001.

    Research output: Contribution to journalReview articlepeer-review

  5. Problems in FMD eradication: a way forward?

    Tulloch, F., Luke, G. A. & Ryan, M. D., 5 Jul 2018, In: Journal of Veterinary Medicine and Research. 5, 5, 6 p., 1140.

    Research output: Contribution to journalReview articlepeer-review

Related by journal

  1. Multiple novel non-canonically transcribed sub-genomic mRNAs produced by avian coronavirus infectious bronchitis virus

    Keep, S., Oade, M. S., Lidzbarski-Silvestre, F., Bentley, K., Stevenson-Leggett, P., Freimanis, G. L., Tennakoon, C., Sanderson, N., Hammond, J. A., Jones, R. C., Britton, P. & Bickerton, E., 28 Jul 2020, In: Journal of General Virology. 16 p., 001474.

    Research output: Contribution to journalArticlepeer-review

  2. Kodoja: a workflow for virus detection in plants using k-mer analysis of RNA-sequencing data

    Baizan-Edge, A., Cock, P., MacFarlane, S., McGavin, W., Torrance, L. & Jones, S., 1 Mar 2019, In: Journal of General Virology. 100, p. 533-542

    Research output: Contribution to journalArticlepeer-review

  3. The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication

    Herod, M. R., Adeyemi, O. O., Ward, J., Bentley, K., Harris, M., Stonehouse, N. J. & Polyak, S. J., 1 Sep 2019, In: Journal of General Virology. 100, 9, p. 1293-1302 10 p.

    Research output: Contribution to journalArticlepeer-review

  4. Impact of human cytomegalovirus on glioblastoma cell viability and chemotherapy treatment

    dos Santos, C. J., Ferreira Castro, F. L., de Aguiar, R. B., Menezes, I. G., Santos, A. C., Paulus, C., Nevels, M. & Carlan da Silva, M. C., Sep 2018, In: Journal of General Virology. 99, 9, p. 1274-1285 12 p.

    Research output: Contribution to journalArticlepeer-review

  5. Mechanisms and consequences of positive-strand RNA virus recombination

    Bentley, K. & Evans, D. J., 1 Oct 2018, In: Journal of General Virology. 99, 10, p. 1345-1356

    Research output: Contribution to journalReview articlepeer-review

Related by journal

  1. Journal of General Virology (Journal)

    Rupert James Martin Russell (Member of editorial board)

    2008 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

  2. Journal of General Virology (Journal)

    Richard Michael Elliott (Editor)

    20082012

    Activity: Publication peer-review and editorial work typesEditor of research journal

  3. Journal of General Virology (Journal)

    Richard Michael Elliott (Member of editorial board)

    20022006

    Activity: Publication peer-review and editorial work typesEditor of research journal

  4. Journal of General Virology (Journal)

    Richard Michael Elliott (Editor)

    19962001

    Activity: Publication peer-review and editorial work typesEditor of research journal

  5. Journal of General Virology (Journal)

    Richard Michael Elliott (Member of editorial board)

    19871991

    Activity: Publication peer-review and editorial work typesEditor of research journal

ID: 255417821

Top