Skip to content

Research at St Andrews

The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration

Research output: Contribution to journalArticlepeer-review

DOI

Open Access permissions

Open

Abstract

Dyslexia is a common neurodevelopmental disorder caused by a significant genetic component. The KIAA0319 gene is one of the most robust dyslexia susceptibility factors but its function remains poorly understood. Initial RNA‐interference studies in rats suggested a role in neuronal migration whereas subsequent work with double knock‐out mouse models for both Kiaa0319 and its paralogue Kiaa0319‐like reported effects in the auditory system but not in neuronal migration. To further understand the role of KIAA0319 during neurodevelopment, we carried out an expression study of its zebrafish orthologue at different embryonic stages. We used different approaches including RNAscope in situ hybridization combined with light‐sheet microscopy. The results show particularly high expression during the first few hours of development. Later, expression becomes localised in well‐defined structures. In addition to high expression in the brain, we report for the first time expression in the eyes and the notochord. Surprisingly, kiaa0319‐like, which generally shows a similar expression pattern to kiaa0319, was not expressed in the notochord suggesting a distinct role for kiaa0319 in this structure. This observation was supported by the identification of notochord enhancers enriched upstream of the KIAA0319 transcription start site, in both zebrafish and humans. This study supports a developmental role for KIAA0319 in the brain as well as in other developing structures, particularly in the notochord which, is key for establishing body patterning in vertebrates.
Close

Details

Original languageEnglish
Pages (from-to)2634-2643
Number of pages10
JournalThe Journal of Comparative Neurology
Volume527
Issue number16
Early online date4 Apr 2019
DOIs
Publication statusPublished - 1 Nov 2019

    Research areas

  • Dyslexia, Development, Zebrafish, Gene expression, Sensory organs, Notochord

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Functional characterization of ATP2C2, a risk factor for language disorders

    Martinelli, A., Diaz, R., Feliciotti, I., Pitt, S. & Paracchini, S., 2019, In: European Neuropsychopharmacology. 29, p. 1194-1195 2 p.

    Research output: Contribution to journalAbstractpeer-review

  2. Light-sheet microscopy with attenuation-compensated propagation-invariant beams

    Nylk, J., McCluskey, K. A., Preciado, M., Mazilu, M., Yang, Z., Gunn-Moore, F. J., Aggarwal, S., Tello, J. A., Ferrier, D. E. K. & Dholakia, K., 6 Apr 2018, In: Science Advances. 4, 4, 13 p., eaar4817.

    Research output: Contribution to journalArticlepeer-review

  3. Multimode fibre based imaging for optically cleared samples

    Gusachenko, I., Nylk, J., Tello, J. A. & Dholakia, K., 1 Nov 2017, In: Biomedical Optics Express. 8, 11, p. 5179-5190

    Research output: Contribution to journalArticlepeer-review

  4. The DCDC2 deletion is not a risk factor for dyslexia

    Scerri, T. S., Macpherson, E., Martinelli, A., Wa, W. C., Monaco, A. P., Stein, J., Zheng, M., Ho, C. S-H., McBride, C., Snowling, M., Hulme, C., Hayiou-Thomas, M. E., Waye, M. M. Y., Talcott, J. B. & Paracchini, S., 25 Jul 2017, In: Translational Psychiatry. 7, 7 p., e1182.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. The sensory peripheral nervous system in the tail of a cephalochordate studied by serial blockface scanning electron microscopy (SBSEM)

    Holland, N. & Somorjai, I. M. L., 15 Oct 2020, In: The Journal of Comparative Neurology. 528, 15, p. 2569-2582 14 p.

    Research output: Contribution to journalArticlepeer-review

  2. Mapping the distribution of language related genes FoxP1, FoxP2, and CntnaP2 in the brains of vocal learning bat species

    Rodenas-Cuadrado, P. M., Mengede, J., Baas, L., Devanna, P., Schmid, T. A., Yartsev, M., Firzlaff, U. & Vernes, S. C., 1 Jun 2018, In: The Journal of Comparative Neurology. 526, 8, p. 1235-1266 32 p.

    Research output: Contribution to journalArticlepeer-review

  3. Corticosterone and Dehydroepiandrosterone Have Opposing Effects on Adult Neuroplasticity in the Avian Song Control System

    Newman, A. E. M., MacDougall-Shackleton, S. A., An, Y-S., Kriengwatana, B. & Soma, K. K., 15 Sep 2010, In: The Journal of Comparative Neurology. 518, 18, p. 3662-3678 17 p.

    Research output: Contribution to journalArticlepeer-review

  4. Distribution of growth hormone-releasing hormone-like peptide: Immunoreactivity in the central nervous system of the adult zebrafish (Danio rerio).

    Castro, A., Becerra, M., Manso, M., Tello, J., Sherwood, N. & Anadon, R., 20 Apr 2009, In: The Journal of Comparative Neurology. 513, 6

    Research output: Contribution to journalArticlepeer-review

ID: 252391932

Top