Skip to content

Research at St Andrews

The evolution of ependymin-related proteins

Research output: Contribution to journalArticle

Standard

The evolution of ependymin-related proteins. / McDougall, Carmel; Hammond, Michael; Dailey, Simon C.; Somorjai, Ildiko M. L.; Cummins, Scott; Degnan, Bernard.

In: BMC Evolutionary Biology, Vol. 18, 182, 04.12.2018.

Research output: Contribution to journalArticle

Harvard

McDougall, C, Hammond, M, Dailey, SC, Somorjai, IML, Cummins, S & Degnan, B 2018, 'The evolution of ependymin-related proteins' BMC Evolutionary Biology, vol. 18, 182. https://doi.org/10.1186/s12862-018-1306-y

APA

McDougall, C., Hammond, M., Dailey, S. C., Somorjai, I. M. L., Cummins, S., & Degnan, B. (2018). The evolution of ependymin-related proteins. BMC Evolutionary Biology, 18, [182]. https://doi.org/10.1186/s12862-018-1306-y

Vancouver

McDougall C, Hammond M, Dailey SC, Somorjai IML, Cummins S, Degnan B. The evolution of ependymin-related proteins. BMC Evolutionary Biology. 2018 Dec 4;18. 182. https://doi.org/10.1186/s12862-018-1306-y

Author

McDougall, Carmel ; Hammond, Michael ; Dailey, Simon C. ; Somorjai, Ildiko M. L. ; Cummins, Scott ; Degnan, Bernard. / The evolution of ependymin-related proteins. In: BMC Evolutionary Biology. 2018 ; Vol. 18.

Bibtex - Download

@article{e56bf9b5efb7427c85b200fae1e07cdf,
title = "The evolution of ependymin-related proteins",
abstract = "Background: Ependymins were originally defined as fish-specific secreted glycoproteins involved in central nervous system plasticity and memory formation. Subsequent research revealed that these proteins represent a fish-specific lineage of a larger ependymin-related protein family (EPDRs). EPDRs have now been identified in a number of bilaterian animals and have been implicated in diverse non-neural functions. The recent discoveries of putative EPDRs in unicellular holozoans and an expanded EPDR family with potential roles in conspecific communication in crown-of-thorns starfish suggest that the distribution and diversity of EPDRs is significantly broader than currently understood.Results:We undertook a systematic survey to determine the distribution and evolution of EPDRs in eukaryotes. In addition to Bilateria, EPDR genes were identified in Cnidaria, Placozoa, Porifera, Choanoflagellatea, Filasterea, Apusozoa, Amoebozoa, Charophyta and Percolozoa, and tentatively in Cercozoa and the orphan group Malawimonadidae. EPDRs appear to be absent from prokaryotes and many eukaryote groups including ecdysozoans, fungi, stramenopiles, alveolates, haptistans and cryptistans. The EPDR family can be divided into two major clades and has undergone lineage-specific expansions in a number of metazoan lineages, including in poriferans, molluscs and cephalochordates. Variation in a core set of conserved residues in EPDRs reveals the presence of three distinct protein types; however, 3D modelling predicts overall protein structures to be similar. Conclusions:  Our results reveal an early eukaryotic origin of the EPDR gene family and a dynamic pattern of gene duplication and gene loss in animals. This research provides a phylogenetic framework for the analysis of the functional evolution of this gene family.",
keywords = "Ependymin, EPDRs, MERPs, Gene duplication, Gene loss",
author = "Carmel McDougall and Michael Hammond and Dailey, {Simon C.} and Somorjai, {Ildiko M. L.} and Scott Cummins and Bernard Degnan",
note = "This research was funded by Australian Research Council grants to BMD and SFC (DP130102543). IMLS gratefully acknowledges start-up funding for her lab from MASTS (Marine Alliance for Science and Technology Scotland) and seedcorn funding through the Wellcome Trust ISSF3 grant number 204821/Z/16/Z.",
year = "2018",
month = "12",
day = "4",
doi = "10.1186/s12862-018-1306-y",
language = "English",
volume = "18",
journal = "BMC Evolutionary Biology",
issn = "1471-2148",
publisher = "BioMed Central",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The evolution of ependymin-related proteins

AU - McDougall, Carmel

AU - Hammond, Michael

AU - Dailey, Simon C.

AU - Somorjai, Ildiko M. L.

AU - Cummins, Scott

AU - Degnan, Bernard

N1 - This research was funded by Australian Research Council grants to BMD and SFC (DP130102543). IMLS gratefully acknowledges start-up funding for her lab from MASTS (Marine Alliance for Science and Technology Scotland) and seedcorn funding through the Wellcome Trust ISSF3 grant number 204821/Z/16/Z.

PY - 2018/12/4

Y1 - 2018/12/4

N2 - Background: Ependymins were originally defined as fish-specific secreted glycoproteins involved in central nervous system plasticity and memory formation. Subsequent research revealed that these proteins represent a fish-specific lineage of a larger ependymin-related protein family (EPDRs). EPDRs have now been identified in a number of bilaterian animals and have been implicated in diverse non-neural functions. The recent discoveries of putative EPDRs in unicellular holozoans and an expanded EPDR family with potential roles in conspecific communication in crown-of-thorns starfish suggest that the distribution and diversity of EPDRs is significantly broader than currently understood.Results:We undertook a systematic survey to determine the distribution and evolution of EPDRs in eukaryotes. In addition to Bilateria, EPDR genes were identified in Cnidaria, Placozoa, Porifera, Choanoflagellatea, Filasterea, Apusozoa, Amoebozoa, Charophyta and Percolozoa, and tentatively in Cercozoa and the orphan group Malawimonadidae. EPDRs appear to be absent from prokaryotes and many eukaryote groups including ecdysozoans, fungi, stramenopiles, alveolates, haptistans and cryptistans. The EPDR family can be divided into two major clades and has undergone lineage-specific expansions in a number of metazoan lineages, including in poriferans, molluscs and cephalochordates. Variation in a core set of conserved residues in EPDRs reveals the presence of three distinct protein types; however, 3D modelling predicts overall protein structures to be similar. Conclusions:  Our results reveal an early eukaryotic origin of the EPDR gene family and a dynamic pattern of gene duplication and gene loss in animals. This research provides a phylogenetic framework for the analysis of the functional evolution of this gene family.

AB - Background: Ependymins were originally defined as fish-specific secreted glycoproteins involved in central nervous system plasticity and memory formation. Subsequent research revealed that these proteins represent a fish-specific lineage of a larger ependymin-related protein family (EPDRs). EPDRs have now been identified in a number of bilaterian animals and have been implicated in diverse non-neural functions. The recent discoveries of putative EPDRs in unicellular holozoans and an expanded EPDR family with potential roles in conspecific communication in crown-of-thorns starfish suggest that the distribution and diversity of EPDRs is significantly broader than currently understood.Results:We undertook a systematic survey to determine the distribution and evolution of EPDRs in eukaryotes. In addition to Bilateria, EPDR genes were identified in Cnidaria, Placozoa, Porifera, Choanoflagellatea, Filasterea, Apusozoa, Amoebozoa, Charophyta and Percolozoa, and tentatively in Cercozoa and the orphan group Malawimonadidae. EPDRs appear to be absent from prokaryotes and many eukaryote groups including ecdysozoans, fungi, stramenopiles, alveolates, haptistans and cryptistans. The EPDR family can be divided into two major clades and has undergone lineage-specific expansions in a number of metazoan lineages, including in poriferans, molluscs and cephalochordates. Variation in a core set of conserved residues in EPDRs reveals the presence of three distinct protein types; however, 3D modelling predicts overall protein structures to be similar. Conclusions:  Our results reveal an early eukaryotic origin of the EPDR gene family and a dynamic pattern of gene duplication and gene loss in animals. This research provides a phylogenetic framework for the analysis of the functional evolution of this gene family.

KW - Ependymin

KW - EPDRs

KW - MERPs

KW - Gene duplication

KW - Gene loss

U2 - 10.1186/s12862-018-1306-y

DO - 10.1186/s12862-018-1306-y

M3 - Article

VL - 18

JO - BMC Evolutionary Biology

T2 - BMC Evolutionary Biology

JF - BMC Evolutionary Biology

SN - 1471-2148

M1 - 182

ER -

Related by author

  1. Light sheet microscopy with acoustic sample confinement

    Yang, Z., Cole, K. L. H., Qiu, Y., Somorjai, I. M. L., Wijesinghe, P., Nylk, J., Cochran, S., Spalding, G. C., Lyons, D. A. & Dholakia, K., 8 Feb 2019, In : Nature Communications. 10, 8 p., 669.

    Research output: Contribution to journalArticle

  2. Amphioxus functional genomics and the origins of vertebrate gene regulation

    Marletaz, F., Firbas, P., Maeso, I., Tena, J., Bogdanovic, O., Perry, M., Wyatt, C., de la Calle-Mustienes, E., Bertrand, S., Burguera, D., Acemel, R., van Heeringen, S., Naranjo, S., Herrera-Ubeda, C., Skvortsova, K., Jimenez-Gancedo, S., Aldea, D., Marquez, Y., Buono, L., Kozmikova, I. & 41 othersPermanyer, J., Louis, A., Albuixech-Crespo, B., Le Petillon, Y., Leon Florian, A., Subirana, L., Balwierz, P. J., Duckett, P., Farahani, E., Aury, J. M., Mangenot, S., Wincker, P., Albalat, R., Benito-Gutierrez, E., Canestro, C., Castro, F., D'Aniello, S., Ferrier, D. E. K., Huang, S., Laudet, V., Marais, G., Pontarotti, P., Schubert, M., Seitz, H., Somorjai, I. M. L., Takahashi, T., Mirabeau, O., Xu, A., Yu, J-K., Carninci, P., Martinez-Morales, J., Crollius, H., Kozmik, Z., Weirauch, M., Garcia-Fernandez, J., Lister, R., Lenhard, B., Holland, P., Escriva, H., Gomez-Skarmeta, J. L. & Irimia, M., 21 Nov 2018, In : Nature. 564, 7734, p. 64-70 29 p.

    Research output: Contribution to journalArticle

  3. Wnt evolution and function shuffling in liberal and conservative chordate genomes

    Somorjai, I. M. L., Marti-Solans, J., Diaz-Gracia, M., Nishida, H., Imai, K., Escriva, H., Cañestro, C. & Albalat, R., 25 Jul 2018, In : Genome Biology. 19, 17 p., 98.

    Research output: Contribution to journalArticle

  4. Pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage

    Barton-Owen, T., Ferrier, D. E. K. & Somorjai, I. M. L., 20 Jun 2018, In : Scientific Reports. 8, 11 p., 9414.

    Research output: Contribution to journalArticle

Related by journal

  1. BMC Evolutionary Biology (Journal)

    David Ellard Keith Ferrier (Editor)
    2017 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

  2. BMC Evolutionary Biology (Journal)

    David Ellard Keith Ferrier (Editor)
    Oct 2016 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

  3. BMC Evolutionary Biology (Journal)

    David Ellard Keith Ferrier (Editor)
    2011 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

  4. BMC Evolutionary Biology (Journal)

    David Ellard Keith Ferrier (Editor)
    2009 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

Related by journal

  1. Two more Posterior Hox genes and Hox cluster dispersal in echinoderms

    Szabó, R. & Ferrier, D. E. K., 27 Dec 2018, In : BMC Evolutionary Biology. 18, 13 p., 203.

    Research output: Contribution to journalArticle

  2. The evolution of social learning mechanisms and cultural phenomena in group foragers

    van der Post, D. J., Franz, M. & Laland, K. N., 10 Feb 2017, In : BMC Evolutionary Biology. 17, 15 p., 49.

    Research output: Contribution to journalArticle

  3. Skill learning and the evolution of social learning mechanisms

    van der Post, D. J., Franz, M. & Laland, K. N., 24 Aug 2016, In : BMC Evolutionary Biology. 16, 19 p., 166.

    Research output: Contribution to journalArticle

  4. TCF/Lef regulates the Gsx ParaHox gene in central nervous system development in chordates

    Garstang, M. G., Osborne, P. & Ferrier, D. E. K., 3 Mar 2016, In : BMC Evolutionary Biology. 16, 19 p., 57.

    Research output: Contribution to journalArticle

ID: 250513259