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The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Research output: Contribution to journalReview articlepeer-review

Author(s)

Jennifer Greaves, Gerald R. Prescott, Oforiwa A. Gorleku, Luke H. Chamberlain

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Abstract

The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

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Details

Original languageEnglish
Pages (from-to)67-79
Number of pages13
JournalMolecular Membrane Biology
Volume26
Issue number1-2
DOIs
Publication statusPublished - 2009

    Research areas

  • Palmitoylation, protein sorting, membrane microdomains, lipid rafts, protein trafficking, CYSTEINE-STRING PROTEIN, GPI-ANCHORED PROTEINS, SRC-FAMILY KINASE, PLASMA-MEMBRANE, LIPID RAFTS, MODEL MEMBRANES, CELL-MEMBRANES, H-RAS, SUBCELLULAR-LOCALIZATION, SACCHAROMYCES-CEREVISIAE

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