Skip to content

Research at St Andrews

The natriuresis following oral administration of the calcium antagonists--nifedipine and nitrendipine

Research output: Contribution to journalArticle

Author(s)

M D Ene, P J Williamson, C J Roberts, G Waddell

School/Research organisations

Abstract

Ten healthy individuals received in random order placebo, nifedipine 10 mg, nifedipine 20 mg, nitrendipine 10 mg and nitrendipine 20 mg as single oral administrations at weekly intervals. On the day before each treatment placebo was administered. Urine was collected for 6 h and then for 18 h after each administration. There was a significant increase in urine volume and sodium excretion after the drugs, but no change in potassium excretion. The effect was most evident in the 6 h after drug administration. The effect was no greater at the higher doses of either drug. A natriuretic-diuretic action of nifedipine and nitrendipine has been confirmed in man. The mechanism of the effect remains unclear.

Close

Details

Original languageEnglish
Pages (from-to)423-7
Number of pages5
JournalBritish Journal of Clinical Pharmacology
Volume19
Issue number4
Publication statusPublished - Apr 1985

    Research areas

  • Administration, Oral, Adolescent, Adult, Calcium Channel Blockers/administration & dosage, Creatinine/urine, Dose-Response Relationship, Drug, Humans, Male, Natriuresis/drug effects, Nifedipine/administration & dosage, Nitrendipine, Potassium/urine

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Non-European doctors and change in UK policy: ten thousand international medical graduates may be affected

    Trewby, P., Williams, G., Williamson, P., Barnes, E., Carr, P., Crilley, J., Foden, A., Mitchell, S. & Murphy, J., 15 Apr 2006, In : British Medical Journal. 332, 7546, p. 913-4 2 p.

    Research output: Contribution to journalLetter

  2. Pohl-Pinkus constrictions of hair following chemotherapy for Hodgkin's disease

    Williamson, P. J. & de Berker, D., Mar 2005, In : British Journal of Haematology. 128, 5, p. 582

    Research output: Contribution to journalLetter

  3. Four pedigrees of the cation-leaky hereditary stomatocytosis class presenting with pseudohyperkalaemia. Novel profile of temperature dependence of Na+–K+ leak in a xerocytic form

    Gore, D. M., Layton, M., Sinha, A. K., Williamson, P. J., Vaidya, B., Connolly, V., Mannix, P., Chetty, M. C., Nicolaou, A. & Stewart, G. W., 19 Apr 2004, In : British Journal of Haematology. 125, 4, p. 521-527 7 p.

    Research output: Contribution to journalArticle

  4. A randomised study comparing an oral regimen with intravenous for consolidation in patients over 55 years with AML in first complete remission

    Jackson, GH., Taylor, PRA., Kaczmarski, R., Mohamed, RJ., Culligan, D., Cullis, J., Littlewood, T., Summerfield, G., Williamson, P. J., Knyba, G. & Samson, D., 2000, In : British Journal of Haematology. 108, supplement

    Research output: Contribution to journalAbstract

  5. Multisystem adverse reaction to lamotrigine

    Schaub, J. E., Williamson, P. J., Barnes, E. W. & Trewby, P. N., 13 Aug 1994, In : Lancet. 344, 8920, p. 481

    Research output: Contribution to journalLetter

Related by journal

  1. Effects of single or combined histamine H-1-receptor and leukotriene CysLT(1)-receptor antagonism on nasal adenosine mono phosphate challenge in persistent allergic rhinitis

    Lee, D. K. C., Jackson, C. M., Soutar, P. C., Fardon, T. C. & Lipworth, B. J., Jun 2004, In : British Journal of Clinical Pharmacology. 57, 6, p. 714-719 6 p.

    Research output: Contribution to journalArticle

  2. Add-on therapy with montelukast or formoterol in patients with the glycine-16 beta(2)-receptor genotype

    Sims, E. J., Jackson, C. M. & Lipworth, B. J., Jul 2003, In : British Journal of Clinical Pharmacology. 56, 1, p. 104-111 8 p.

    Research output: Contribution to journalArticle

  3. Comparison of combination inhalers vs inhaled corticosteroids alone in moderate persistent asthma

    Lee, D. K. C., Jackson, C. M., Currie, G. P., Cockburn, W. J. & Lipworth, B. J., Nov 2003, In : British Journal of Clinical Pharmacology. 56, 5, p. 494-500 7 p.

    Research output: Contribution to journalArticle

  4. Influences on plasma cortisol of different formulations of beclomethasone dipropionate

    Lipworth, B. J. & Jackson, C. M., Oct 2000, In : British Journal of Clinical Pharmacology. 50, 4, p. 381-381 1 p.

    Research output: Contribution to journalLetter

  5. Pharmacokinetics of chlorofluorocarbon and hydrofluoroalkane metered-dose inhaler formulations of beclomethasone dipropionate

    Lipworth, B. J. & Jackson, C. M., 1999, In : British Journal of Clinical Pharmacology. 48, 6, p. 866-868 3 p.

    Research output: Contribution to journalArticle

ID: 255029972

Top